{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:24:37Z","timestamp":1740137077463,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,7]],"date-time":"2017-05-07T00:00:00Z","timestamp":1494115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Stichting Hartedroom"},{"DOI":"10.13039\/501100013428","name":"Stichting Spieren voor spieren","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013428","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009622","name":"Zeldzame ziekten fonds","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009622","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to evaluate the predicting value of quantitative and qualitative dyssynchrony parameters as assessed by two\u2010dimensional speckle tracking echocardiography (<jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>) on outcome in children with dilated cardiomyopathy (<jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>). Furthermore, the reproducibility of these parameters was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>In previous studies in adults with heart failure, several dyssynchrony parameters have been shown to be a valuable predictor of clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter, prospective study included 75 children with <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> and 75 healthy age\u2010matched controls. Using <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>, quantitative (time to global peak strain and parameters describing intraventricular time differences) and qualitative dyssynchrony parameters (pattern analysis) of the apical four\u2010chamber, three\u2010chamber, two\u2010chamber views, and the short axis of the left ventricle were assessed. Cox regression was used to identify risk factors for the primary endpoints of death or heart transplantation. Inter\u2010observer and intra\u2010observer variability were described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median of 21\u00a0months follow\u2010up, 10 patients (13%) reached an endpoint. Although quantitative dyssynchrony measures were higher in patients as compared to controls, the inter\u2010observer and intra\u2010observer variability were high. Pattern analysis showed mainly reduced strain, instead of dyssynchronous patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, quantitative dyssynchrony parameters were not reproducible, precluding their use in children. Qualitative pattern analysis showed predominantly reduced strain, suggesting that in children with <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content> dyssynchrony may be a minor problem.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13548","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T04:44:46Z","timestamp":1494218686000},"page":"881-887","source":"Crossref","is-referenced-by-count":6,"title":["Distribution of strain patterns in children with dilated cardiomyopathy"],"prefix":"10.1111","volume":"34","author":[{"given":"Susanna L.","family":"den Boer","sequence":"first","affiliation":[{"name":"Departments of Pediatrics Division of Pediatric Cardiology Sophia Children's Hospital Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon J.","family":"du Marchie Sarvaas","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics Division of Pediatric Cardiology Beatrix Children's Hospital University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liselotte M.","family":"Klitsie","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics Division of Pediatric Cardiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabri\u00eblle G.","family":"van Iperen","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics Division of Pediatric Cardiology Wilhelmina Children's Hospital University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald B.","family":"Tanke","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics Division of Pediatric Cardiology Radboud University Medical Center  Nijmegen The 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