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This study aimed to investigate the factors associated with <jats:styled-content style=\"fixed-case\">ARD<\/jats:styled-content> in patients with surgically repaired ventricular septal defect (<jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included 152 patients with surgically repaired <jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content>. Two definitions of <jats:styled-content style=\"fixed-case\">ARD<\/jats:styled-content> were used: (1) observed Valsalva diameter to body surface area (<jats:styled-content style=\"fixed-case\">BSA<\/jats:styled-content>) ratio &gt;2.1\u00a0cm\/m<jats:sup>2<\/jats:sup> and (2) absolute value of Valsalva diameter \u22654.0\u00a0cm. Odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s) of <jats:styled-content style=\"fixed-case\">ARD<\/jats:styled-content> presence were calculated using multivariate logistic regressions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">ARD<\/jats:styled-content> ranged between 8.6% and 32.9%. Using the definition of observed aortic root diameter\/<jats:styled-content style=\"fixed-case\">BSA<\/jats:styled-content> &gt;2.1\u00a0cm\/m<jats:sup>2<\/jats:sup>, patients with nonsubarterial <jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content> type were more likely to have <jats:styled-content style=\"fixed-case\">ARD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.65, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>; 1.83\u201317.44, <jats:italic>P<\/jats:italic>=.003) than those with subarterial type, and patients with preoperative right\u2010 or noncoronary cusp prolapse (<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NCCP<\/jats:styled-content>) were more likely to have <jats:styled-content style=\"fixed-case\">ARD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.68, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>; 1.20\u201311.23, <jats:italic>P<\/jats:italic>=.022) than patients without preoperative <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NCCP<\/jats:styled-content> after adjustment for sex, age at repair (ie, shunt duration), <jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content> size, and postoperative follow\u2010up period. Using the definition of absolute Valsalva diameter \u22654\u00a0cm, nonsubarterial <jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content> type and presence of <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NCCP<\/jats:styled-content> were also significantly associated with <jats:styled-content style=\"fixed-case\">ARD<\/jats:styled-content> after adjustment for the same covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anatomical and morphological features (nonsubarterial type and presence of preoperative <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NCCP<\/jats:styled-content>) are independently correlated with <jats:styled-content style=\"fixed-case\">ARD<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content> regardless of the different definitions of <jats:styled-content style=\"fixed-case\">ARD<\/jats:styled-content>. Patients with surgically repaired <jats:styled-content style=\"fixed-case\">VSD<\/jats:styled-content> may need careful monitoring for potential <jats:styled-content style=\"fixed-case\">ARD<\/jats:styled-content> development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13622","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T05:22:53Z","timestamp":1499318573000},"page":"1203-1209","source":"Crossref","is-referenced-by-count":3,"title":["Factors associated with aortic root dilatation after surgically repaired ventricular septal defect"],"prefix":"10.1111","volume":"34","author":[{"given":"Chihiro","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noritoshi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University  Tokyo Japan"},{"name":"Department of Preventive Medicine and Public Health Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5215-4488","authenticated-orcid":false,"given":"Keiko","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goki","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyomi","family":"Ashihara","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhisa","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2069.149515"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2013.43.4.215"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2012.08.018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.10.025"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)37013-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.4.414"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61339-6"},{"issue":"2","key":"e_1_2_8_9_1","first-page":"I38","article-title":"Second natural history study of congenital heart defects. 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