{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:27:24Z","timestamp":1793298444815,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Objective<\/jats:title>We aimed to research left atrial (LA<\/jats:styled-content>) phasic function and heart rate variability (HRV<\/jats:styled-content>), as well as their relationship, in subjects with uncomplicated systemic sclerosis (SS<\/jats:styled-content>c).<\/jats:p><\/jats:sec>Methods<\/jats:title>The investigation involved 44 SS<\/jats:styled-content>c patients and 33 age\u2010matched healthy controls. All participants underwent clinical examination, serological tests, 24\u2010hours Holter monitoring, and echocardiographic examination including strain analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>Maximum, minimum, and pre\u2010A LA<\/jats:styled-content> volumes and volume indices were higher in the SS<\/jats:styled-content>c patients than in the controls. The total emptying fraction, the parameter of the LA<\/jats:styled-content> reservoir function, as well as passive LA<\/jats:styled-content> emptying fraction, which represents the LA<\/jats:styled-content> conduit function, were significantly lower in the SS<\/jats:styled-content>c patients compared to the controls. Active LA<\/jats:styled-content> emptying fraction, the parameter of the LA<\/jats:styled-content> booster pump function, was significantly higher in the SS<\/jats:styled-content>c participants. There was no difference in LA<\/jats:styled-content> reservoir function between the diffuse and the limited SS<\/jats:styled-content>c form. LA<\/jats:styled-content> conduit function was significantly decreased, whereas LA<\/jats:styled-content> booster pump function was compensatory increased in the diffuse SS<\/jats:styled-content>c form compared to the limited SS<\/jats:styled-content>c form. Similar results were obtained by LA<\/jats:styled-content> strain analysis. HRV<\/jats:styled-content> indices were significantly decreased in the SS<\/jats:styled-content>c patients. Modified Rodnan skin score, the parameter of skin involvement in SS<\/jats:styled-content>c, and HRV<\/jats:styled-content> indices correlated well with LA<\/jats:styled-content> phasic function in SS<\/jats:styled-content>c.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Left atrial (LA<\/jats:styled-content>) phasic function, assessed by both volumetric and strain method, as well as cardiac autonomic nervous function is significantly deteriorated in SS<\/jats:styled-content>c patients. Skin score and HRV<\/jats:styled-content> indices correlate with LA<\/jats:styled-content> phasic function parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13648","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T07:04:40Z","timestamp":1502089480000},"page":"1447-1455","source":"Crossref","is-referenced-by-count":9,"title":["Left atrial phasic function and heart rate variability in patients with systemic sclerosis: A new part of the old puzzle"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6235-5152","authenticated-orcid":false,"given":"Marijana","family":"Tadic","sequence":"first","affiliation":[{"name":"Cardiology Department University Clinical Hospital Center \u201cDr. Dragisa Misovic \u2010 Dedinje,\u201d Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Zlatanovic","sequence":"additional","affiliation":[{"name":"Institute of Rheumatology Belgrade 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