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We assessed 719 Caucasian and African American participants of the <jats:styled-content style=\"fixed-case\">CARDIA<\/jats:styled-content> study, with echocardiograms and brain <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> at follow\u2010up year 25 (2010\u20132011). Echocardiography assessed aortic root diameter; <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>; circumferential, longitudinal, and radial deformation. Cerebral <jats:styled-content style=\"fixed-case\">MRI DTI<\/jats:styled-content>, and, on a subset, <jats:styled-content style=\"fixed-case\">ASL<\/jats:styled-content> perfusion sequences were used to assess white matter fractional anisotropy and gray matter cerebral blood flow (<jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content>). Linear regression explored relations between cardiac parameters and cerebral measures, adjusting for anthropometrics, risk factors, and brain constitutional variation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age 50\u00a0\u00b1\u00a04\u00a0years, <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> 118\u00a0\u00b1\u00a015\u00a0mm\u00a0Hg; 60% white, and 48% men. Mean <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> was 46\u00a0\u00b1\u00a09\u00a0mL\/100\u00a0g\/min, and white matter fractional anisotropy was 0.31\u00a0\u00b1\u00a00.02. Worse circumferential deformation and larger aortic root were related to worse white matter fractional anisotropy. Worse radial systolic deformation was related to worse <jats:styled-content style=\"fixed-case\">CBF<\/jats:styled-content> in multivariable models. <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> did not relate to early brain abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In spite of no apparent effect of <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> ejection fraction, early subclinical cardiac dysfunction and brain abnormalities are present and associated in middle\u2010aged generally healthy individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13695","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T08:51:55Z","timestamp":1510131115000},"page":"1617-1622","source":"Crossref","is-referenced-by-count":14,"title":["Association of early left ventricular dysfunction with advanced magnetic resonance white matter and gray matter brain measures: The <scp>CARDIA<\/scp> study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-8922","authenticated-orcid":false,"given":"Anderson C.","family":"Armstrong","sequence":"first","affiliation":[{"name":"Johns Hopkins University Baltimore MD USA"},{"name":"Universidade Federal do Vale do S\u00e3o Francisco Petrolina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majon","family":"Muller","sequence":"additional","affiliation":[{"name":"LEDB\/NIA\/NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharath","family":"Ambale\u2010Ventakesh","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Halstead","sequence":"additional","affiliation":[{"name":"LEDB\/NIA\/NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Kishi","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Bryan","sequence":"additional","affiliation":[{"name":"Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Sidney","sequence":"additional","affiliation":[{"name":"Health System Kaiser Permanente Northern California Division of Research Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds C. L.","family":"Correia","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Gidding","sequence":"additional","affiliation":[{"name":"A. I. duPont Hospital for Children Wilmington DE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore J.","family":"Launer","sequence":"additional","affiliation":[{"name":"LEDB\/NIA\/NIH Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o A. 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