{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:24:48Z","timestamp":1740137088503,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Beijing Key Laboratory of Maternal-Fetal Medicine in Fetal Heart Disease","award":["BZ0308"],"award-info":[{"award-number":["BZ0308"]}]},{"name":"Beijing Municipal Administration of Hospitals Project","award":["XMLX201604"],"award-info":[{"award-number":["XMLX201604"]}]},{"name":"Beijing Laboratory for Cardiovascular Precision Medicine","award":["116211"],"award-info":[{"award-number":["116211"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to investigate pulmonary hypoplasia (<jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>) and associated risk factors in fetuses with congenital conotruncal defect (<jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 75 fetuses with <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content> (gestational age (GA): 22\u201332\u00a0weeks) and 150 normal GA\u2010matched fetuses as the control group were studied. We measured diameters of aorta (Ao); main, left, and right pulmonary artery (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>); and their Z\u2010scores by fetal echocardiography (<jats:styled-content style=\"fixed-case\">FE<\/jats:styled-content>). We also measured the lung area, lung area\/chest area ratio (<jats:styled-content style=\"fixed-case\">LCR<\/jats:styled-content>), lung\u2010to\u2010head circumference ratio (<jats:styled-content style=\"fixed-case\">LHR<\/jats:styled-content>), right lung area\/head circumference<jats:sup>2<\/jats:sup> (quantitative lung index, <jats:styled-content style=\"fixed-case\">QLI<\/jats:styled-content>), and Z\u2010scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>, left pulmonary artery (<jats:styled-content style=\"fixed-case\">LPA<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">RPA<\/jats:styled-content>, and their Z\u2010scores and the lung area measurements (except for <jats:styled-content style=\"fixed-case\">QLI<\/jats:styled-content>) were significantly smaller in the <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content> group, compared with the normal control group. Subgroup analysis showed the following: (1) <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content> with right ventricular outflow tract obstruction (<jats:styled-content style=\"fixed-case\">RVOTO<\/jats:styled-content>) had smaller main and branch <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> dimensions and small lung areas in contrast to <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content> without <jats:styled-content style=\"fixed-case\">RVOTO<\/jats:styled-content>. (2) <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content> with pulmonary atresia had smaller <jats:styled-content style=\"fixed-case\">LPA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RPA<\/jats:styled-content> dimensions but no difference in lung areas. (3) In the common types of <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>, lung area variables were mostly smaller in double outlet right ventricle (<jats:styled-content style=\"fixed-case\">DORV<\/jats:styled-content>) and tetralogy of Fallot (<jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content>), but there was no difference in transposition of the great arteries (<jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content> is associated with hypoplastic main and branch pulmonary arteries as well as <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>. Risk factors for <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> included defect types (<jats:styled-content style=\"fixed-case\">DORV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TOF<\/jats:styled-content> but not <jats:styled-content style=\"fixed-case\">TGA<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">RVOTO<\/jats:styled-content>. It is plausible that pulmonary blood flow, rather than the type of <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> RVOTO<\/jats:styled-content>, or pulmonary artery dimensions, plays a key role in <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13701","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T17:16:31Z","timestamp":1514567791000},"page":"1842-1851","source":"Crossref","is-referenced-by-count":6,"title":["Pulmonary hypoplasia in fetuses with congenital conotruncal defects"],"prefix":"10.1111","volume":"34","author":[{"given":"Qian","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Maternal\u2010Fetal Medicine and Fetal Heart Disease Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Maternal\u2010Fetal Medicine and Fetal Heart Disease Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Han","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Maternal\u2010Fetal Medicine and Fetal Heart Disease Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Maternal\u2010Fetal Medicine and Fetal Heart Disease Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7280-4329","authenticated-orcid":false,"given":"Shuping","family":"Ge","sequence":"additional","affiliation":[{"name":"The Heart Center St. Christopher's Hospital for Children and Drexel University College of Medicine  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6857-3516","authenticated-orcid":false,"given":"Yihua","family":"He","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Maternal\u2010Fetal Medicine and Fetal Heart Disease Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,29]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1136\/thx.37.12.893"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1371\/journal.pone.0093557"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1002\/aja.1000710303"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1016\/j.echo.2004.04.011"},{"volume-title":"Prenatal ultrasound diagnosis and perinatal management guidelines of fetal cardiology","year":"2015","author":"He YH","key":"e_1_2_6_6_1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1002\/uog.2597"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1002\/uog.2651"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1016\/S0002-9378(96)70165-5"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1016\/j.ajog.2011.07.031"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.4103\/0971-9784.179589"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1159\/000082441"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1046\/j.1469-0705.1998.11010013.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1161\/01.RES.57.6.811"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.13701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.13701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T23:59:34Z","timestamp":1696031974000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.13701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/echo.13701"],"URL":"https:\/\/doi.org\/10.1111\/echo.13701","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"type":"print","value":"0742-2822"},{"type":"electronic","value":"1540-8175"}],"subject":[],"published":{"date-parts":[[2017,12]]}}}