{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:10:12Z","timestamp":1788207012086,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,24]],"date-time":"2017-09-24T00:00:00Z","timestamp":1506211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Young Core Fund of Zhongshan Hospital, Fudan University.","award":["(NO.2015ZSYXGG04)"],"award-info":[{"award-number":["(NO.2015ZSYXGG04)"]}]},{"DOI":"10.13039\/501100001809","name":"The National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["(N0.81201095)"],"award-info":[{"award-number":["(N0.81201095)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>As growing numbers of long\u2010term cancer survivors faced with the cardiac side effects by anthracycline treatment, it is necessary to explore the optimal monitoring method for the early detection of cardiac toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis of 82 consecutive patients with diffuse large B\u2010cell lymphoma treated with chemotherapy. Echocardiographic Doppler imaging\u2010derived Tei index and mitral annular peak systolic velocity (Sm) measured by tissue Doppler imaging <jats:styled-content style=\"fixed-case\">TDI<\/jats:styled-content>, serum high\u2010sensitivity cardiac troponin T (hs\u2010<jats:styled-content style=\"fixed-case\">cTnT<\/jats:styled-content>) levels, and left ventricular ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>) by multigated radionuclide angiography (<jats:styled-content style=\"fixed-case\">MUGA<\/jats:styled-content>) were obtained before, after 2\u20134, and after 6\u20138 chemotherapy cycles. Cardiotoxicity was defined as a relative reduction of <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> \u226510% from the baseline or <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> &lt;50% as measured by MUGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following chemotherapy, 24 (29.3%) patients developed detectable cardiac abnormality during the treatment. Five (6.1%) patients' cardiac function changed from normal baseline <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> to &lt;50% after the chemotherapy. Echocardiographic pulse wave Doppler Tei index (<jats:styled-content style=\"fixed-case\">PW<\/jats:styled-content> Tei index) (baseline 0.347\u00a0\u00b1\u00a00.115 vs 2\u20134 cycles 0.459\u00a0\u00b1\u00a00.161 vs 6\u20138 cycles 0.424\u00a0\u00b1\u00a00.139, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.000) inversely correlated with systolic (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and diastolic dysfunction (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Serum hs\u2010<jats:styled-content style=\"fixed-case\">cTnT<\/jats:styled-content> levels increased significantly following chemotherapy after 2\u20134 cycles of chemotherapy with anthracycline. The increase in <jats:styled-content style=\"fixed-case\">PW<\/jats:styled-content> Tei index of 0.095 [sensitivity, 69.2%; specificity, 64.5%; area under the curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>)\u00a0=\u00a00.697; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005] and the Sm\u00a0&lt;\u00a013.65\u00a0cm\/s (sensitivity, 66.7%; specificity, 71%; <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\u00a0=\u00a00.682; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.009) combined with elevation of serum hs\u2010<jats:styled-content style=\"fixed-case\">cTnT<\/jats:styled-content> level of 0.0075\u00a0ng\/mL (sensitivity, 69.2%; specificity, 83.9%; <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\u00a0=\u00a00.790; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) after 2\u20134 chemotherapy cycles from the baseline values can reliably predict cardiotoxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We demonstrated that echocardiographic <jats:styled-content style=\"fixed-case\">PW<\/jats:styled-content> Doppler\u2010derived Tei index, and <jats:styled-content style=\"fixed-case\">TDI<\/jats:styled-content>\u2010derived Sm, combined with serum hs\u2010<jats:styled-content style=\"fixed-case\">cTnT<\/jats:styled-content> level can be obtained in outpatient settings to monitor early cardiac toxicity induced by anthracycline therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13704","type":"journal-article","created":{"date-parts":[[2017,9,24]],"date-time":"2017-09-24T08:12:55Z","timestamp":1506240775000},"page":"1593-1600","source":"Crossref","is-referenced-by-count":23,"title":["Early anthracycline\u2010induced cardiotoxicity monitored by echocardiographic Doppler parameters combined with serum hs\u2010<scp>cTnT<\/scp>"],"prefix":"10.1111","volume":"34","author":[{"given":"Chu\u2010Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Echocardiography Shanghai Institute of Cardiovascular Diseases Shanghai Institute of Medical Imaging Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Li","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Echocardiography Shanghai Institute of Cardiovascular Diseases Shanghai Institute of Medical Imaging Zhongshan Hospital Fudan University Shanghai China"},{"name":"Department of Cardiology Kashgar Prefecture Second People's Hospital Xinjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei\u2010Yan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Echocardiography Shanghai Institute of Cardiovascular Diseases Shanghai Institute of Medical Imaging Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun\u2010Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian\u2010Hong","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Echocardiography Shanghai Institute of Cardiovascular Diseases Shanghai Institute of Medical Imaging Zhongshan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Hsi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Columbia University College of Physicians &amp; 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