{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:59:40Z","timestamp":1769601580312,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Objectives<\/jats:title>To assess efficacy, safety, outcomes, and intrauterine complications following maternal hyperoxygenation (MH<\/jats:styled-content>) therapy in fetuses with congenital heart disease (CHD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>A systematic review was performed following an electronic search of databases. Articles were published before January 1, 2017, in an English\u2010language and non\u2013English\u2010language journals (with English translations), and included human fetuses and expectant mothers with a fetal diagnosis of CHD<\/jats:styled-content> who received MH<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Ninety\u2010six articles were identified; 72 were excluded and 24 full\u2010text articles were reviewed. Only 9 articles met inclusion criteria and were analyzed. A total of 270 fetuses underwent MH<\/jats:styled-content> therapy: 169 had CHD<\/jats:styled-content>, and 101 had normal heart anatomies. Seven studies used fetal echocardiography, while 2 studies used cardiac magnetic resonance imaging (CMR<\/jats:styled-content>). The mean gestational age at therapy was 33.4\u00a0weeks (26\u201338\u00a0weeks). Majority of MH<\/jats:styled-content> protocols used 100% FiO2<\/jats:sub> with non\u2010rebreather face mask at 8\u00a0L of flow, achieving 60%\u201370% FiO2<\/jats:sub>, or maternal PaO2<\/jats:sub> goal of 250\u00a0mm\u00a0Hg. No significant adverse events were reported. Four studies reported increased size of the hypoplastic cardiac structures after MH<\/jats:styled-content>. Three studies utilized acute MH<\/jats:styled-content> to risk stratify hypoplastic left heart syndrome fetuses. Two studies assessed acute MH<\/jats:styled-content> in the setting of CMR<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The current evidence for MH<\/jats:styled-content> therapy suggests an increase in pulmonary blood flow, and venous return, ductal flow, and heart dimensions in fetuses. MH<\/jats:styled-content> has potential as a diagnostic and therapeutic tool in fetuses with CHD<\/jats:styled-content>. Further randomized controlled trials are needed to ascertain whether MH<\/jats:styled-content> therapy provides improved outcomes on fetuses with certain types of CHD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13722","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T17:16:31Z","timestamp":1514567791000},"page":"1822-1833","source":"Crossref","is-referenced-by-count":36,"title":["Maternal hyperoxygenation: A potential therapy for congenital heart disease in the fetuses? A systematic review of the current literature"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7937-4384","authenticated-orcid":false,"given":"Jennifer","family":"Co\u2010Vu","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Congenital Heart Center University of Florida College of Medicine Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia","family":"Lopez\u2010Colon","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Congenital Heart Center University of Florida College of Medicine Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himesh V.","family":"Vyas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Congenital Heart Center University of Florida College of Medicine Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Weiner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Congenital Heart Center University of Florida College of Medicine Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curt","family":"DeGroff","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Congenital Heart Center University of Florida College of Medicine Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15846"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4025"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951114001802"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(01)80063-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14688"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.3.257"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.848432"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01780-X"},{"key":"e_1_2_6_10_1","first-page":"CD000137","article-title":"Maternal oxygen administration for suspected impaired fetal growth","volume":"1","author":"Say L","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-009-9600-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.11.075"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39304"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4762"},{"key":"e_1_2_6_15_1","first-page":"195","article-title":"Pulmonary vasoreactivity to materno\u2010fetal hyperoxygenation testing in fetuses with hypoplastic left heart","volume":"37","author":"Enzensberger C","year":"2016","journal-title":"Ultraschall Med"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(15)60514-9"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.13722","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.13722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T23:59:46Z","timestamp":1696031986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.13722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/echo.13722"],"URL":"https:\/\/doi.org\/10.1111\/echo.13722","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]}}}