{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:24:45Z","timestamp":1740137085905,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,29]],"date-time":"2017-10-29T00:00:00Z","timestamp":1509235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>It was this study's objective to evaluate the echocardiographic characteristics and flow patterns in abdominal arteries of Fontan patients before the onset of protein\u2010losing enteropathy (PLE) or plastic bronchitis (PB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>In this retrospective cohort investigation, we examined 170 Fontan patients from 32 different centers who had undergone echocardiographic and Doppler ultrasound examinations between June 2006 and May 2013. Follow\u2010up questionnaires were completed by 105 patients a median of 5.3 (1.5\u20138.5) years later to evaluate whether one of the complications had occurred since the examinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 91 patients never developed PLE or PB (\u201cnon\u2010PLE\/PB\u201d); they were compared to 14 affected patients. Eight of the 14 patients had already been diagnosed with \u201cpresent PLE\/PB\u201d when examined. Six \u201cfuture PLE\/PB\u201d patients developed those complications later on and were identified on follow\u2010up. The \u201cfuture PLE\/PB\u201d patients presented significantly slower diastolic flow velocities in the celiac artery (0.1 (0.1\u20130.5) m\/s vs 0.3 (0.1\u20131.0) m\/s (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04) and in the superior mesenteric artery (0.0 (0.0\u20130.2) m\/s vs 0.2 (0.0\u20130.6) m\/s, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) than the \u201cnon\u2010PLE\/PB\u201d group. Median resistance indices in the celiac artery were significantly higher (0.9 (0.8\u20130.9) m\/s vs 0.8 (0.6\u20130.9) m\/s, (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01)) even before the onset of PLE or PB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An elevated flow resistance in the celiac artery may prevail in Fontan patients before the clinical manifestation of PLE or PB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13737","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T03:04:35Z","timestamp":1509332675000},"page":"79-84","source":"Crossref","is-referenced-by-count":2,"title":["Echocardiographic characteristics in Fontan patients before the onset of protein\u2010losing enteropathy or plastic bronchitis"],"prefix":"10.1111","volume":"35","author":[{"given":"Florian","family":"Du Bois","sequence":"first","affiliation":[{"name":"University Heart Center Freiburg\u2014Bad Krozingen Department of Congenital Heart Disease and Pediatric Cardiology Medical Center\u2014University of Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Stiller","sequence":"additional","affiliation":[{"name":"University Heart Center Freiburg\u2014Bad Krozingen Department of Congenital Heart Disease and Pediatric Cardiology Medical Center\u2014University of Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Borth\u2010Bruhns","sequence":"additional","affiliation":[{"name":"Nachsorgeklinik Tannheim, Rehabilitation Clinic  Tannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Unseld","sequence":"additional","affiliation":[{"name":"University Heart Center Freiburg\u2014Bad Krozingen Department of Congenital Heart Disease and Pediatric Cardiology Medical Center\u2014University of Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rouven","family":"Kubicki","sequence":"additional","affiliation":[{"name":"University Heart Center Freiburg\u2014Bad Krozingen Department of Congenital Heart Disease and Pediatric Cardiology Medical Center\u2014University of Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Hoehn","sequence":"additional","affiliation":[{"name":"University Heart Center Freiburg\u2014Bad Krozingen Department of Congenital Heart Disease and Pediatric Cardiology Medical Center\u2014University of Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Reineker","sequence":"additional","affiliation":[{"name":"University Heart Center Freiburg\u2014Bad Krozingen Department of Congenital Heart Disease and Pediatric Cardiology Medical Center\u2014University of Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Grohmann","sequence":"additional","affiliation":[{"name":"University Heart Center Freiburg\u2014Bad Krozingen Department of Congenital Heart Disease and Pediatric Cardiology Medical Center\u2014University of Freiburg Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4531-5930","authenticated-orcid":false,"given":"Thilo","family":"Fleck","sequence":"additional","affiliation":[{"name":"University Heart Center Freiburg\u2014Bad Krozingen Department of Congenital Heart Disease and Pediatric Cardiology Medical Center\u2014University of Freiburg Faculty of Medicine University of Freiburg  Freiburg 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