{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T23:14:24Z","timestamp":1776294864028,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Background<\/jats:title>In patients with severe aortic regurgitation (AR<\/jats:styled-content>), the left ventricular ejection fraction (LVEF<\/jats:styled-content>) and left ventricle (LV<\/jats:styled-content>) size are crucial for determining clinical prognosis and timing of valve intervention. In clinical practice, LV<\/jats:styled-content> internal diameters obtained at end\u2010diastole are used to assess the degree of LV<\/jats:styled-content> dilatation. Whether quantification of LV<\/jats:styled-content> volumes would provide more robust information as compared to LV<\/jats:styled-content> linear dimensions is unknown.<\/jats:p><\/jats:sec>Methods<\/jats:title>We retrospectively analyzed preoperative and postoperative transthoracic echocardiograms of patients who underwent aortic valve replacement (AVR<\/jats:styled-content>) for severe AR<\/jats:styled-content>. Indexed linear LV<\/jats:styled-content> end\u2010diastolic and end\u2010systolic diameters along with indexed LV<\/jats:styled-content> end\u2010diastolic and end\u2010systolic volumes were obtained as per current guidelines. Post\u2010AVR LV<\/jats:styled-content> reverse remodeling, defined as \u226510% reduction in measures of LV<\/jats:styled-content> volumes (Teichholz and Simpson's methods), was determined. Positive and negative agreement was calculated between the volume\u2010 and diameter\u2010based LV<\/jats:styled-content> reverse remodeling.<\/jats:p><\/jats:sec>Results<\/jats:title>Sixty\u2010two consecutive patients were included. Nine patients (17%) without LV<\/jats:styled-content> reverse remodeling based on Teichholz were reclassified as having LV<\/jats:styled-content> reverse remodeling based on Simpson (positive agreement 0.846 [95% CI<\/jats:styled-content> 0.772, 0.921], negative agreement 0.200 [95% CI<\/jats:styled-content> \u22120.350, 0.435]). Left ventricle (LV<\/jats:styled-content>) reverse remodeling assessed by the Teichholz method was underestimated by a mean of 31\u00a0mL\/m2<\/jats:sup> (\u03b2\u00a0=\u00a0\u22120.65 [95% CI<\/jats:styled-content> \u22121.06 to \u22120.24], P<\/jats:italic>\u00a0=\u00a0.003) compared to Simpson method.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Compared to the volume\u2010based method, diameter\u2010based LV<\/jats:styled-content> measurement incorrectly identified LV<\/jats:styled-content> reverse remodeling post\u2010AVR<\/jats:styled-content> in 17% of patients with severe AR<\/jats:styled-content>. Left ventricle (LV<\/jats:styled-content>) volume may be a better measure to assess LV<\/jats:styled-content> remodeling post\u2010AVR<\/jats:styled-content> than LV<\/jats:styled-content> diameter\u2010based measurements.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13750","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:08:56Z","timestamp":1511975336000},"page":"142-147","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of left ventricular reverse remodeling in patients with severe aortic regurgitation undergoing aortic valve replacement: Comparison between diameters and volumes"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1454-918X","authenticated-orcid":false,"given":"G\u00e9raldine","family":"Ong","sequence":"first","affiliation":[{"name":"Department of Cardiology St. Michael's Hospital Toronto ON Canada"},{"name":"Clinical Trial Center Cardiovascular Research Foundation New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjorn","family":"Redfors","sequence":"additional","affiliation":[{"name":"Clinical Trial Center Cardiovascular Research Foundation New York NY USA"},{"name":"Department of Cardiology Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Crowley","sequence":"additional","affiliation":[{"name":"Clinical Trial Center Cardiovascular Research Foundation New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Husam","family":"Abdel\u2010Qadir","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Michael's Hospital Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana","family":"Harrington","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery St. Michael's Hospital Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Trial Center Cardiovascular Research Foundation New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Lafreni\u00e8re\u2010Roula","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children Toronto ON Canada"},{"name":"University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Leong\u2010Poi","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Michael's Hospital Toronto ON Canada"},{"name":"University of Toronto Toronto ON Canada"},{"name":"Keenan Research Centre St. Michael's Hospital Li Ka Shing Knowledge Institute Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery St. Michael's Hospital Toronto ON Canada"},{"name":"University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim A.","family":"Connelly","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Michael's Hospital Toronto ON Canada"},{"name":"University of Toronto Toronto ON Canada"},{"name":"Keenan Research Centre St. Michael's Hospital Li Ka Shing Knowledge Institute Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.536"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF01145320","article-title":"Left ventricular remodeling in chronic aortic regurgitation","volume":"9","author":"Bartella G","year":"1993","journal-title":"Int J Card 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