{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:14:24Z","timestamp":1780377264218,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:00:00Z","timestamp":1511740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The closure of atrial septal defect (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>) results in normalized left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) and right ventricular (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) geometry, and can increase <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> stroke volume (<jats:styled-content style=\"fixed-case\">LVSV<\/jats:styled-content>), but the parameters associated with this increase after the closure of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> remain uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> patients, who underwent transcatheter closure, were studied. Their mean age was 57.80\u00a0\u00b1\u00a016.88\u00a0years, 42 (60%) were female, and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>) was 66.76%\u00a0\u00b1\u00a07.91% (all \u226555%). Transthoracic echocardiography was performed before and 3\u00a0months after the procedure. Global longitudinal strain (<jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>) was determined as the average peak speckle tracking strain of 18 segments from the 3 standard apical views, <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> dispersion was defined as standard deviation of time\u2010to\u2010peak strain from the same views, and <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> systolic function was calculated by averaging the 3\u2010regional peak speckle tracking longitudinal strains from the <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> free wall. A significant relative increase in <jats:styled-content style=\"fixed-case\">LVSV<\/jats:styled-content> between before and 3\u00a0months after the closure was defined as \u2206<jats:styled-content style=\"fixed-case\">LVSV<\/jats:styled-content> \u226515%. Twenty age\u2010, gender\u2010, and <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>\u2010matched controls served as the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Global longitudinal strain (<jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> free wall strain were similar for <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> patients and controls, but <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> dispersion in <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> patients was significantly larger. Global longitudinal strain (<jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>) remained unchanged after transcatheter closure, whereas <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> free wall strain and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> dispersion decreased significantly. An important finding of the multivariate logistic regression analysis showed that \u2206<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> dispersion was the only independent determinant of increased <jats:styled-content style=\"fixed-case\">LVSV<\/jats:styled-content> after the closure (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.023; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.001\u20131.046; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The assessment of <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> dispersion may well have clinical implications for better management of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> patients after transcatheter closure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13757","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T17:57:21Z","timestamp":1511805441000},"page":"218-226","source":"Crossref","is-referenced-by-count":3,"title":["Left ventricular dispersion as a parameter for augmented left ventricular stroke volume in patients with atrial septal defect following transcatheter closure"],"prefix":"10.1111","volume":"35","author":[{"given":"Yutaka","family":"Hatani","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-7039","authenticated-orcid":false,"given":"Hidekazu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Internal Medicine Kobe University Graduate School of Medicine  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