{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:06:22Z","timestamp":1791446782481,"version":"4.3.3"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Background<\/jats:title>Left atrial (LA<\/jats:styled-content>) dysfunction, expressed as impaired LA<\/jats:styled-content> deformation using two\u2010dimensional (2D) strain imaging, has been observed in association with rheumatic mitral stenosis (MS<\/jats:styled-content>). However, the clinical role of speckle tracking echocardiography (STE<\/jats:styled-content>)\u2010derived LA<\/jats:styled-content> strain has rarely been studied in MS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Aim<\/jats:title>This study aimed to identify the determinants of New York Heart Association (NYHA<\/jats:styled-content>) functional class in patients with mitral stenosis and to investigate the relationship between left atrial deformation as measured by two\u2010dimensional STE<\/jats:styled-content>\u2010derived LA<\/jats:styled-content> strain and heart failure symptoms.<\/jats:p><\/jats:sec>Methods<\/jats:title>Sixty\u2010nine consecutive patients (20 males and 49 females; mean age: 61\u00a0\u00b1\u00a014\u00a0years) with rheumatic MS<\/jats:styled-content> were evaluated using comprehensive 2D and color Doppler echocardiography including STE<\/jats:styled-content>\u2010derived LA<\/jats:styled-content> strain (LAS<\/jats:styled-content>) and peak positive filling strain rate (LASR<\/jats:styled-content>r) during the LA<\/jats:styled-content> reservoir phase. Those results were then correlated with NYHA<\/jats:styled-content> functional class.<\/jats:p><\/jats:sec>Results<\/jats:title>There were 15 (22%) patients in functional class I, 42 (61%) in functional class II<\/jats:styled-content>, and 12 (17%) in functional class III<\/jats:styled-content>. There were no significant differences in mitral valve area, pressure gradient, pulmonary artery pressure, LA<\/jats:styled-content> emptying fraction, or left ventricular ejection fraction between functional classes. Upon multivariate analysis (controlling for diuretics usage), LAS<\/jats:styled-content> (\u00df\u00a0=\u00a0\u22120.233, P<\/jats:italic>\u00a0=\u00a0.045) and LASR<\/jats:styled-content>r (\u00df\u00a0=\u00a0\u22120.277, P<\/jats:italic>\u00a0=\u00a0.014) were independent factors in determining NYHA<\/jats:styled-content> functional class.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In stable patients with MS<\/jats:styled-content>, NYHA<\/jats:styled-content> functional class independently correlated with LAS<\/jats:styled-content> and LASR<\/jats:styled-content>r. Left atrial (LA<\/jats:styled-content>) deformation correlated with heart failure symptoms in patients with MS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13770","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T06:56:52Z","timestamp":1512975412000},"page":"190-195","source":"Crossref","is-referenced-by-count":28,"title":["Atrial deformation correlated with functional capacity in mitral stenosis patients"],"prefix":"10.1111","volume":"35","author":[{"given":"Chen\u2010Yu","family":"Chien","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan"},{"name":"School of Medicine Tzu Chi 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