{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:00:29Z","timestamp":1792569629539,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:00:00Z","timestamp":1518998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Background<\/jats:title>Fabry disease (FD<\/jats:styled-content>) and hypertrophic cardiomyopathy (HCM<\/jats:styled-content>) are two diseases with a different pathophysiology, both cause left ventricular hypertrophy (LVH<\/jats:styled-content>) and myocardial fibrosis. Although remodeling and systolic dysfunction of the left atrium (LA<\/jats:styled-content>) are associated with atrial fibrillation and stroke in HCM<\/jats:styled-content>, changes in the size and function of the LA<\/jats:styled-content> have not been well studied in FD<\/jats:styled-content> with LVH<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>The following groups were studied prospectively, and their respective findings compared: 19 patients with non\u2010obstructive HCM (Group I), 20 patients with a diagnosis of Fabry cardiomyopathy (Group II), and 20 normal subjects matched for sex and age (Group III). Left ventricular mass index was measured using Devereux\u2019 formula, left atrial volume with Simpson\u2019s biplane method and left atrial mechanical function, including strain and strain rate, was measured using the speckle tracking technique. Strain and strain rate of the reservoir were measured during the three phases: reservoir (SR S), passive conduit (SR E) and atrial contraction (SR A).<\/jats:p><\/jats:sec>Results<\/jats:title>Patients with HCM<\/jats:styled-content> had a larger left atrial volume than patients with FD<\/jats:styled-content> (48.16\u00a0\u00b1\u00a014.3\u00a0mL\/m2<\/jats:sup> vs 38.9\u00a0\u00b1\u00a014.9\u00a0mL\/m2<\/jats:sup> respectively, P\u00a0<\/jats:italic><\u00a0.001), but in both disorders there was a severe decrease in left atrial function: reservoir strain in the apical four\u2010chamber view: 17.47% in HCM<\/jats:styled-content> vs 22.5% in FD<\/jats:styled-content>, P<\/jats:italic>\u00a0=\u00a0.24), strain rate in the apical chamber view: SR<\/jats:styled-content> A: \u22120.80\/seconds in HCM<\/jats:styled-content> vs \u22121.04\/seconds in FD<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a0.88), SR<\/jats:styled-content> S: 0.69\/seconds in HCM<\/jats:styled-content> vs 0.93 in FD<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a0.12), SR<\/jats:styled-content> E: \u22120.80\u00a0seconds in HCM<\/jats:styled-content> vs \u22120.97\/seconds in FD<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a0.18).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In this echocardiographic study we used speckle tracking to assess left atrial mechanical function and showed that FD<\/jats:styled-content> is associated to an atrial cardiomyopathy, affecting the three phasic functions of the LA<\/jats:styled-content>. Although in patients with HCM<\/jats:styled-content> left atrial volume is larger than in patients with FD<\/jats:styled-content>, both disorders exhibit severe decrease in left atrial function. These findings should be considered, given the potentially serious complications that can occur with the two diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13829","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T16:50:00Z","timestamp":1519231800000},"page":"643-650","source":"Crossref","is-referenced-by-count":20,"title":["Comparison of left atrial size and function in hypertrophic cardiomyopathy and in Fabry disease with left ventricular hypertrophy"],"prefix":"10.1111","volume":"35","author":[{"given":"Mar\u00eda Cristina","family":"Saccheri","sequence":"first","affiliation":[{"name":"Echocardiography Laboratory Division of Cardiology Hospital General de Agudos del Gobierno de la Ciudad de Buenos Aires \u201cDr. Cosme Argerich Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5815-1173","authenticated-orcid":false,"given":"Tom\u00e1s Francisco","family":"Cianciulli","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory Division of Cardiology Hospital General de Agudos del Gobierno de la Ciudad de Buenos Aires \u201cDr. Cosme Argerich Buenos Aires Argentina"},{"name":"Researcher of the Ministry of Health of the Government of the City of Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilde","family":"Challapa Licidio","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory Division of Cardiology Hospital General de Agudos del Gobierno de la Ciudad de Buenos Aires \u201cDr. Cosme Argerich Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Lax","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory Division of Cardiology Hospital General de Agudos del Gobierno de la Ciudad de Buenos Aires \u201cDr. Cosme Argerich Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn A.","family":"Beck","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory Division of Cardiology Hospital General de Agudos del Gobierno de la Ciudad de Buenos Aires \u201cDr. Cosme Argerich Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Morita","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory Division of Cardiology Hospital General de Agudos del Gobierno de la Ciudad de Buenos Aires \u201cDr. Cosme Argerich Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory Division of Cardiology Hospital General de Agudos del Gobierno de la Ciudad de Buenos Aires \u201cDr. Cosme Argerich Buenos Aires Argentina"},{"name":"Researcher of the Ministry of Health of the 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