{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:53:28Z","timestamp":1779314008283,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Aims<\/jats:title>Two\u2010dimensional speckle tracking echocardiography (2DSTE<\/jats:styled-content>) detects early signs of left ventricular dysfunction; however, it is unknown whether layer\u2010specific global longitudinal strain (GLS<\/jats:styled-content>) has incremental value in diagnosis of patients with reversible ischemia assessed by single photon emission computed tomography (SPECT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods and Results<\/jats:title>Eighty patients with stable angina pectoris (SAP<\/jats:styled-content>), normal left ventricular ejection fraction (LVEF<\/jats:styled-content>), and no history of ischemic heart disease were retrospectively identified to have been examined by 2DSTE<\/jats:styled-content>, SPECT<\/jats:styled-content>, and coronary angiography (CAG<\/jats:styled-content>). Patients with a normal SPECT<\/jats:styled-content> constituted the control group, and patients with a positive SPECT<\/jats:styled-content> were divided into patients with or without (true\u2010 or false\u2010 positive SPECT<\/jats:styled-content>) significant stenosis assessed by CAG<\/jats:styled-content>. GLS<\/jats:styled-content> was measured for two myocardial layers (endocardial and epicardial) and as well as mid\u2010myocardial GLS<\/jats:styled-content>. Patients with reversible ischemia had significantly lower GLS<\/jats:styled-content> compared to the control group (GLSE<\/jats:sub><\/jats:styled-content>ndocardial<\/jats:sub>: \u221219.0\u00a0\u00b1\u00a04.4% vs \u221221.4\u00a0\u00b1\u00a03.7%, P<\/jats:italic>\u00a0=\u00a0.011; GLSE<\/jats:sub><\/jats:styled-content>picardial<\/jats:sub>: \u221214.3\u00a0\u00b1\u00a02.9% vs \u221216.3\u00a0\u00b1\u00a02.9%, P<\/jats:italic>\u00a0=\u00a0.004); GLSM<\/jats:sub><\/jats:styled-content>id\u2010myocardial<\/jats:sub>: \u221216.5\u00a0\u00b1\u00a03.6% vs \u221218.6\u00a0\u00b1\u00a03.2%, P<\/jats:italic>\u00a0=\u00a0.006. This difference was even more evident in patients with a true\u2010positive SPECT<\/jats:styled-content> (GLSE<\/jats:sub><\/jats:styled-content>ndocardial<\/jats:sub>: \u221218.0\u00a0\u00b1\u00a04.4% vs \u221221.4\u00a0\u00b1\u00a03.7%, P<\/jats:italic>\u00a0<\u00a0.001; GLSE<\/jats:sub><\/jats:styled-content>picardial<\/jats:sub>: \u221213.6\u00a0\u00b1\u00a03.0% vs \u221216.3\u00a0\u00b1\u00a02.9%, P<\/jats:italic>\u00a0<\u00a0.001); GLSM<\/jats:sub><\/jats:styled-content>id\u2010myocardial<\/jats:sub>: \u221215.6\u00a0\u00b1\u00a03.6% vs \u221218.6\u00a0\u00b1\u00a03.2%, P<\/jats:italic>\u00a0<\u00a0.001. Notably, no significant differences existed in patients with a false\u2010positive SPECT<\/jats:styled-content>. GLSE<\/jats:sub><\/jats:styled-content>picardial<\/jats:sub> was the only independent predictor of coronary artery disease.<\/jats:p><\/jats:sec>In conclusion<\/jats:title>In patients with SAP<\/jats:styled-content> and preserved LVEF<\/jats:styled-content>, layer\u2010specific GLS<\/jats:styled-content> at rest identifies patients with reversible ischemia. This seems to be evident only in patients with a true\u2010positive SPECT<\/jats:styled-content>, thus, 2DSTE<\/jats:styled-content> at rest might improve the diagnostic accuracy of a positive SPECT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13830","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T06:39:14Z","timestamp":1518676754000},"page":"632-642","source":"Crossref","is-referenced-by-count":20,"title":["Layer\u2010specific global longitudinal strain reveals impaired cardiac function in patients with reversible ischemia"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6917-3223","authenticated-orcid":false,"given":"Christoffer E.","family":"Hagemann","sequence":"first","affiliation":[{"name":"Department of Cardiology Herlev & Gentofte Hospital Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev & Gentofte Hospital Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9511-8375","authenticated-orcid":false,"given":"Flemming J.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev & Gentofte Hospital Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev & Gentofte Hospital Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Fritz\u2010Hansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev & Gentofte Hospital Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan S.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev & Gentofte Hospital Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tor","family":"Biering\u2010S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Herlev & Gentofte Hospital Faculty of Health Sciences University of Copenhagen Copenhagen 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