{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:16:48Z","timestamp":1758637008120,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foundation of Research and Business, Chungnam National University, Daejeon, South Korea"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Although cardiac manifestation of Beh\u00e7et disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) has been described in sporadic reports, its timely diagnosis remains difficult. The objective of this study was to describe early cardiac manifestations of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>. We also performed a comprehensive classification of systemic <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> activity and compared their cardiac manifestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective screening using speckle tracking echocardiography was performed in 85 patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> who had no history of heart disease. After excluding subjects with left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>) &lt;50% (n\u00a0=\u00a01), atrial fibrillation (n\u00a0=\u00a02), or inadequate echocardiographic images (n\u00a0=\u00a01), we analyzed their clinical and echocardiographic parameters including <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> global longitudinal strains (<jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>) and compared them with those of an age\u2010 and gender\u2010matched control group (n\u00a0=\u00a0145). Systemic <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> activity was classified as minimal (Group A), controlled (Group B), and active (Group C).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 81 study patients (59 females, age of 51\u00a0\u00b1\u00a011\u00a0years), echocardiography revealed a mean <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> of 64\u00a0\u00b1\u00a05% without any significant valvular dysfunction or aortic aneurysm. Although there was no difference in <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> between the control group and the patient group, the patient group showed significant reduction in <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content> (\u201017.1\u00a0\u00b1\u00a02.9% vs \u201020.8\u00a0\u00b1\u00a02.2%, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.001). Groups A (n\u00a0=\u00a021, 26%), B (n\u00a0=\u00a047, 58%), and C (n\u00a0=\u00a013, 58%) consistently showed reduction in <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content> compared with the control group. However, there was no significant difference in cardiac manifestations among these groups according to systemic disease activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> present intrinsic <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> dysfunction despite no apparent abnormality on routine echocardiography. However, their cardiac manifestations are not proportional to systemic <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> activity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13844","type":"journal-article","created":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T17:32:42Z","timestamp":1518802362000},"page":"809-816","source":"Crossref","is-referenced-by-count":6,"title":["Intrinsic changes of left ventricular function in patients with Beh\u00e7et disease and comparison according to systemic disease activity"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6019-4343","authenticated-orcid":false,"given":"Byung Joo","family":"Sun","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine School of Medicine Chungnam National University Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Hyeong","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine School of Medicine Chungnam National University Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su\u2010Jin","family":"Yoo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine School of Medicine Chungnam National University Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunseon","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiac Imaging Laboratory Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiac Imaging Laboratory Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Suk","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiac Imaging Laboratory Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine School of Medicine Chungnam National University Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Seol","family":"Yoo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine School of Medicine Chungnam National University Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Cheol","family":"Shim","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine School of Medicine Chungnam National University Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Wook","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Department of Internal Medicine School of Medicine Chungnam National University Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine School of Medicine Chungnam National University Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine School of Medicine Chungnam National University Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si Wan","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine School of Medicine Chungnam National University Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Ok","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine School of Medicine Chungnam National University Chungnam National University Hospital  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u2010Whan","family":"Seong","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine School of Medicine Chungnam National University Chungnam National University Hospital  Daejeon 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