{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:57:13Z","timestamp":1790261833154,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007186","name":"Jonsson Comprehensive Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007186","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Anthracyclines are widely used to treat solid and hematologic malignancies, but are known to cause cardiotoxicity. As more childhood cancer survivors reach adulthood due to improvements in oncologic treatments, they become susceptible to late and progressive anthracycline\u2010induced cardiotoxicity. Nonetheless, diagnostic criteria for early detection of cardiac dysfunction are not well defined in children, adolescent, and young adults (CAYA, ages 1\u201340\u00a0years). We present a natural history of the changes in myocardial deformation in CAYA patients after anthracycline therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a literature review search between 2001 and 2016 using PubMed with the following search terms: strain (or deformation), torsion (or twist), children (or adolescent or young adult), cardiotoxicity (or dysfunction), and anthracyclines (or doxorubicin). A total of 23 articles were reviewed. Fourteen articles were incorporated in the meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Strain abnormalities are observed at both short\u2010term and long\u2010term follow\u2010up. Global longitudinal strain (GLS) abnormalities are common during or early after chemotherapy, whereas changes in global circumferential strain (GCS) are more significant and consistent on long\u2010term follow\u2010up. Although global radial strain and torsional parameters are also often abnormal late after chemotherapy, there are few studies evaluating these parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There are significant abnormalities in GLS and GCS following anthracycline therapy acutely and late after treatment. The prognostic value of these strain abnormalities warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13871","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T02:06:36Z","timestamp":1522461996000},"page":"922-934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Natural history of myocardial deformation in children, adolescents, and young adults exposed to anthracyclines: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"35","author":[{"given":"Mirela","family":"Tuzovic","sequence":"first","affiliation":[{"name":"Division of Cardiology David Geffen School of Medicine at UCLA  Los Angeles CA USA"},{"name":"Division of Cardiology VA Greater Los Angeles Healthcare System  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Tzu","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Cardiology David Geffen School of Medicine at UCLA  Los Angeles CA USA"},{"name":"Division of Cardiology VA Greater Los Angeles Healthcare System  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Kianmahd","sequence":"additional","affiliation":[{"name":"Division of Cardiology David Geffen School of Medicine at UCLA  Los Angeles CA USA"},{"name":"Division of Cardiology VA Greater Los Angeles Healthcare System  Los Angeles CA USA"},{"name":"School of Medicine Stony Brook University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8854-2976","authenticated-orcid":false,"given":"Kim\u2010Lien","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Cardiology David Geffen School of Medicine at UCLA  Los Angeles CA USA"},{"name":"Division of Cardiology VA Greater Los Angeles Healthcare System  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.195"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335649"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340311799960645"},{"key":"e_1_2_6_5_1","first-page":"3","article-title":"The discovery of daunorubicin","volume":"65","author":"Di Marco A","year":"1981","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.923"},{"key":"e_1_2_6_7_1","unstructured":"American Cancer Society. 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