{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:16:21Z","timestamp":1755926181985,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Background<\/jats:title>Left ventricular noncompaction (LVNC<\/jats:styled-content>) is associated with progressive LV<\/jats:styled-content> systolic dysfunction and dilated cardiomyopathy. We aimed to investigate the echocardiographic and clinical characteristics associated with LV<\/jats:styled-content> ejection fraction (LVEF<\/jats:styled-content>) and moderate or greater systolic dysfunction in patients with LVNC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Our institutional echocardiography database was retrospectively reviewed between 2008 and 2014, and 62 patients with LVNC<\/jats:styled-content> were identified. Forty\u2010three (69%) had moderate or greater LV<\/jats:styled-content> systolic dysfunction (LVEF<\/jats:styled-content>\u00a0\u2264\u00a040%) and were compared with 19 (31%) patients with preserved or mildly reduced LVEF<\/jats:styled-content> (>40%). Linear regression analyses were utilized to identify markers associated with LVEF<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>The mean age was 63\u00a0\u00b1\u00a017\u00a0years and noncompacted\u2010to\u2010compacted ratio was 2.3\u00a0\u00b1\u00a00.5, and was larger in patients with LVEF<\/jats:styled-content>\u00a0\u2264\u00a040% (2.4 vs 2.1; P<\/jats:italic>\u00a0=\u00a0.02). Patients with LVEF<\/jats:styled-content>\u00a0\u2264\u00a040% were older, had more congestive heart failure, significant QRS<\/jats:styled-content> interval prolongation, and greater LV<\/jats:styled-content> remodeling and worse mean global longitudinal strain (GLS<\/jats:styled-content>). Multivariate regression analysis revealed increased age (standardized regression coefficient (\u03b2)\u00a0=\u00a0\u22120.17; P<\/jats:italic>\u00a0=\u00a0.04) and QRS<\/jats:styled-content> duration (\u03b2\u00a0=\u00a0\u22120.13; P<\/jats:italic>\u00a0=\u00a0.08), congestive heart failure (\u03b2\u00a0=\u00a0\u22120.18; P<\/jats:italic>\u00a0=\u00a0.04), and worsened GLS<\/jats:styled-content> (\u03b2\u00a0=\u00a0\u22120.40; P<\/jats:italic>\u00a0=\u00a0.001) were independently associated with decreased LVEF<\/jats:styled-content> in the cohort (overall model fit R<\/jats:italic>2\u00a0<\/jats:sup>=\u00a00.71; P<\/jats:italic>\u00a0<\u00a0.0001). Increased age (\u03b2\u00a0=\u00a0\u22120.49; P<\/jats:italic>\u00a0=\u00a0.01) and QRS<\/jats:styled-content> duration (\u03b2\u00a0=\u00a0\u22120.50; P<\/jats:italic>\u00a0=\u00a0.002), and worsened GLS<\/jats:styled-content> (\u03b2\u00a0=\u00a0\u22120.33; P<\/jats:italic>\u00a0=\u00a0.04), were also associated with a lower LVEF<\/jats:styled-content> in patients with LVEF<\/jats:styled-content>\u00a0>\u00a040%.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The independent markers associated with LVEF<\/jats:styled-content> and moderate or greater LV<\/jats:styled-content> systolic dysfunction in patients with LVNC<\/jats:styled-content>, in particular GLS<\/jats:styled-content> and QRS<\/jats:styled-content> duration, may detect high\u2010risk candidates for more aggressive clinical surveillance and medical therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13873","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T01:26:36Z","timestamp":1522027596000},"page":"941-948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Echocardiographic and clinical markers of left ventricular ejection fraction and moderate or greater systolic dysfunction in left ventricular noncompaction cardiomyopathy"],"prefix":"10.1111","volume":"35","author":[{"given":"Ivan A.","family":"Arenas","sequence":"first","affiliation":[{"name":"Echocardiography Laboratory Division of Cardiology Columbia University Mount Sinai Heart Institute Miami Beach FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6338-4791","authenticated-orcid":false,"given":"Christos G.","family":"Mihos","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory Division of Cardiology Columbia University Mount Sinai Heart Institute Miami Beach FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doreen","family":"DeFaria Yeh","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Program Massachusetts General Hospital Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evin","family":"Yucel","sequence":"additional","affiliation":[{"name":"Cardiac Ultrasound Laboratory Massachusetts General Hospital Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hany M.","family":"Elmahdy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mount Sinai Medical Center Miami Beach FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando","family":"Santana","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory Division of Cardiology Columbia University Mount 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