{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:21:00Z","timestamp":1765268460249,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R00\u2010HL\u2010107642","K23HL123533"],"award-info":[{"award-number":["R00\u2010HL\u2010107642","K23HL123533"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Background<\/jats:title>Prior studies have shown that both heart failure (HF<\/jats:styled-content>) and atrial fibrillation (AF<\/jats:styled-content>) are factors that impact left atrial function and structure. However, right atrial (RA<\/jats:styled-content>) function measured as RA<\/jats:styled-content> emptying fraction (RAEF<\/jats:styled-content>) on echocardiography has not been analyzed systematically in a chronic HF<\/jats:styled-content> population. The aim of this study was to assess RA<\/jats:styled-content> volume index (RAVI<\/jats:styled-content>) and RAEF<\/jats:styled-content> in patients with chronic HF<\/jats:styled-content> and patients with hypertension (HTN<\/jats:styled-content>) and to relate these findings to other cardiopulmonary ultrasound parameters and 12\u2010month outcomes.<\/jats:p><\/jats:sec>Methods and Results<\/jats:title>In this prospective observational study, we identified 119 patients with chronic HF<\/jats:styled-content> (64 patients without a history of AF<\/jats:styled-content> [HF<\/jats:styled-content> without AF<\/jats:styled-content>], 55 with AF<\/jats:styled-content> [HF<\/jats:styled-content> with AF<\/jats:styled-content>]), and 127 patients with HTN<\/jats:styled-content> but without important cardiac disease who underwent routine outpatient transthoracic echocardiography. We found that RAEF<\/jats:styled-content> was impaired in patients with HF<\/jats:styled-content> without AF<\/jats:styled-content> compared to patients with HTN<\/jats:styled-content> (35% \u00b12 vs 50% \u00b11, P<\/jats:italic>\u00a0<\u00a0.001), whereas RAVI<\/jats:styled-content> did not differ between these two groups. Lower RAEF<\/jats:styled-content> was associated with larger RAVI<\/jats:styled-content> and higher estimated RA<\/jats:styled-content> pressures but not with a higher degree of pulmonary congestion by lung ultrasound. Both lower RAEF<\/jats:styled-content> and higher RAVI<\/jats:styled-content> were associated with an increased risk of 12\u2010month HF<\/jats:styled-content> hospitalizations or all\u2010cause death (age, sex, and AF<\/jats:styled-content> adjusted HR<\/jats:styled-content>: 4.07, 95% CI<\/jats:styled-content>: 1.69\u20139.79; P<\/jats:italic>\u00a0=\u00a0.002, vs 2.74, 95% CI<\/jats:styled-content>: 1.15\u20136.54, P<\/jats:italic>\u00a0=\u00a0.023).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In an outpatient HF<\/jats:styled-content> cohort, both lower RAEF<\/jats:styled-content> and increased RAVI<\/jats:styled-content> were associated with other markers of impaired cardiac function and 12\u2010month adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13876","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T07:16:53Z","timestamp":1522394213000},"page":"905-914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Right atrial structure and function in patients with hypertension and with chronic heart failure"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0711-3502","authenticated-orcid":false,"given":"Moritz","family":"Proplesch","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Brigham and Women's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison A.","family":"Merz","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian L.","family":"Claggett","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA USA"},{"name":"Cardiovascular Division Brigham and Women's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldrin F.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA USA"},{"name":"Cardiovascular Division Brigham and Women's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin H.","family":"Dwyer","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Rhode Island Hospital Brown Medical School Providence RI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela R.","family":"Crousillat","sequence":"additional","affiliation":[{"name":"Department of Cardiology Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily S.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Cardiology Massachusetts General Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montane B.","family":"Silverman","sequence":"additional","affiliation":[{"name":"F. Edward Hebert School of Medicine Uniformed Services University of the Health Sciences Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Peck","sequence":"additional","affiliation":[{"name":"Royal College of Surgeons in Ireland Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Rivero","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA USA"},{"name":"Cardiovascular Division Brigham and Women's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA USA"},{"name":"Cardiovascular Division Brigham and Women's Hospital Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Platz","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Brigham and Women's Hospital Boston MA USA"},{"name":"Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.004010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001276"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01887.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht500"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02864-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0682"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.05.031"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.01.051"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2009.01.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173245"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/682218"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-016-0883-3"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197112232852601"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.06.065"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12735"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12346"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv745"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000156"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-008-9306-4"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.08.013"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/AC.66.6.2136957"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03373-8"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.07.066"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.10.009"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.09.133"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes003"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.13876","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.13876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T18:16:45Z","timestamp":1694715405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.13876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,30]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/echo.13876"],"URL":"https:\/\/doi.org\/10.1111\/echo.13876","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"type":"print","value":"0742-2822"},{"type":"electronic","value":"1540-8175"}],"subject":[],"published":{"date-parts":[[2018,3,30]]},"assertion":[{"value":"2018-03-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}