{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:57:52Z","timestamp":1790175472639,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Our aim was to investigate the relation between left atrial stiffness (<jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content>t) and thoracic aortic plaque thickness in hypertensive patients with stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 97 hypertensive patients were recruited (age: 59.2\u00a0\u00b1\u00a07.5\u00a0years), including 56 consecutive patients with undefined stroke and 41 age\u2010matched hypertensive patients without stroke. Left atrial strain and stiffness were measured using speckle tracking echo. Thoracic aortic plaque detection and evaluation was performed using transesophageal echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hypertensive patients with stroke, when compared with those without stroke, had a significantly higher <jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content>t value (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The percentage of plaque 1\u20134\u00a0mm thickness were comparable in both groups (23.2% vs 21.9%; <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). While the percentage of plaque \u22654\u00a0mm thickness was much higher in hypertensive patients with stroke (71.4% vs 4.9%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). <jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content>t was considerably increased in hypertensive group with paroxysmal atrial fibrillation (<jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content>) when compared to hypertensive group without <jats:styled-content style=\"fixed-case\">PAF<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). A significant positive correlation was found between the <jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content>t and plaque thickness (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Multivariate analysis showed that <jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content>t was the strongest independent predictor for \u22654\u00a0mm aortic plaque thickness (Hazard ratio\u00a0=\u00a06.153; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). With receiver operating characteristic (<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) curve analysis, <jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content>t\u00a0&gt;\u00a00.63 was the best cutoff value in predicting aortic plaque thickness\u00a0\u2265\u00a04\u00a0mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Left atrial stiffness was significantly associated with aortic plaque thickness\u00a0\u2265\u00a04\u00a0mm, in hypertensive patients with stroke. These finding prevailed the importance of <jats:styled-content style=\"fixed-case\">LAS<\/jats:styled-content>t in risk stratification of hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13877","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:22:12Z","timestamp":1523319732000},"page":"949-956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between left atrial stiffness and aortic plaque thickness in hypertensive patients with stroke"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4052-6440","authenticated-orcid":false,"given":"Ragab A.","family":"Mahfouz","sequence":"first","affiliation":[{"name":"Cardiology Department Zagazig University Hospital  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam","family":"Galal","sequence":"additional","affiliation":[{"name":"Cardiology 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