{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:22:17Z","timestamp":1780730537724,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T00:00:00Z","timestamp":1523491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Objective<\/jats:title>To evaluate atrial and ventricular parameters using real time three\u2010dimensional transthoracic echocardiography (RT<\/jats:styled-content>3DTTE<\/jats:styled-content>) in women treated with nifedipine in the early third trimester (III<\/jats:styled-content>\u2010T) of pregnancy.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective single\u2010subject design study in a university\u2010affiliated hospital, where each participant served as her own control. We studied 25 pregnant women at a gestational age of 25\u201333\u00a0weeks with TPTL<\/jats:styled-content> prior to vs 48\u00a0hours postnifedipine treatment. Two\u2010dimensional transthoracic echocardiography (2DTTE<\/jats:styled-content>) and RT<\/jats:styled-content>3DTTE<\/jats:styled-content> were used to study 3D left atrial (LA<\/jats:styled-content>) volumes and indexes, emptying fraction, left ventricular and LA<\/jats:styled-content> cavities, and total vascular resistance (TVR<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Two\u2010dimensional transthoracic echocardiography showed a significant increase in LA<\/jats:styled-content> area (from 15.2\u00a0\u00b1\u00a02.62 to 16.16\u00a0\u00b1\u00a02.21\u00a0mm2<\/jats:sup>, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.02) before vs after nifedipine; RT<\/jats:styled-content>3DTTE<\/jats:styled-content> showed a significant change in LA<\/jats:styled-content> end\u2010diastolic volume index (from 23.7\u00a0\u00b1\u00a04.2 to 26.75\u00a0\u00b1\u00a03.8\u00a0mL\/m2<\/jats:sup>, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.008). LA<\/jats:styled-content> end\u2010systolic volume and index were not significantly different before vs after nifedipine (from 24.56\u00a0\u00b1\u00a08 to 25.3\u00a0\u00b1\u00a05.5\u00a0mL, from 13.6\u00a0\u00b1\u00a05.3 to 14.8\u00a0\u00b1\u00a03.4\u00a0mL\/m2<\/jats:sup>); P\u00a0<\/jats:italic>>\u00a0<\/jats:italic>.05, respectively. E\/a ratio, E\u2010tdi, and E\/E\u2010tdi did not change significantly ([from 2.54\u00a0\u00b1\u00a04.46 to 2.54\u00a0\u00b1\u00a04.1], [from 11.9\u00a0\u00b1\u00a01.9 to 11.9\u00a0\u00b1\u00a02], [from 7.8\u00a0\u00b1\u00a01.4 to 7.6\u00a0\u00b1\u00a01.1], respectively, P\u00a0<\/jats:italic>>\u00a0<\/jats:italic>.05). Tricuspid annular plane systolic excursion (TAPSE<\/jats:styled-content>) did not change significantly from 23.77\u00a0\u00b1\u00a04.2 to 23.9\u00a0\u00b1\u00a03.3, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.1. There was a significant decrease in pulmonary pressure (from 25.4\u00a0\u00b1\u00a04.2 to 23\u00a0\u00b1\u00a02.5\u00a0mm\u00a0Hg, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.02), in mean arterial pressure (from 80\u00a0\u00b1\u00a04 to 76\u00a0\u00b1\u00a03\u00a0mm\u00a0Hg, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001) and in TVR<\/jats:styled-content> (from 1160\u00a0\u00b1\u00a0260 to 1050\u00a0\u00b1\u00a0206\u00a0dyne\u00a0s\/cm\u22125<\/jats:sup>, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.04).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>According to RT<\/jats:styled-content>3DTTE<\/jats:styled-content> measurements, in pregnant women treated with nifedipine for tocolysis, there were no detrimental cardiovascular effects detected 48\u00a0hours postnifedipine treatment. RT<\/jats:styled-content>3DTTE<\/jats:styled-content> could show accurately the compensatory response of the left heart to the cardiovascular changes induced by treatment with nifedipine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13884","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T14:07:53Z","timestamp":1523542073000},"page":"1164-1170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Safety of nifedipine in threatened preterm labor: Investigation by three\u2010dimensional echocardiography"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4552-4428","authenticated-orcid":false,"given":"Leonti","family":"Grin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Barzilai University Medical Center Ashkelon Israel"},{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva 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