{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T12:45:51Z","timestamp":1772455551068,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Italian Ministry of the University","award":["2015JSWLTN"],"award-info":[{"award-number":["2015JSWLTN"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) diastolic dysfunction (<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>) is a frequent finding in obesity and may predispose to the development of heart failure (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>). However, no data are available on the prevalence of <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> after the introduction of the 2016 Recommendations of the American Society of Echocardiography and the European Association of Cardiovascular Imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>To assess the impact of the new Recommendations on the prevalence of <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> and on their clinical and echocardiographic correlates in obesity, a prospective study was performed in 588 subjects with an ejection fraction (<jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content>) \u226550% and no history of <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> either obese (n\u00a0=\u00a0402; mean age: 47\u00a0\u00b1\u00a012\u00a0years; women 71%; body mass index [<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>]: 44\u00a0\u00b1\u00a08\u00a0kg\/m<jats:sup>2<\/jats:sup>), overweight (n\u00a0=\u00a086; <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>: 28\u00a0\u00b1\u00a01\u00a0kg\/m<jats:sup>2<\/jats:sup>), or with a normal weight (n\u00a0=\u00a0100; <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>: 22\u00a0\u00b1\u00a02\u00a0kg\/m<jats:sup>2<\/jats:sup>). All subjects underwent an echocardiographic and Doppler study, including the assessment of global longitudinal strain (<jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> occurred in 19% of obese patients, 12% of overweight subjects, and 2% of normal weight subjects. We used multivariable logistic analysis to assess the risk of <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>. In patients with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> \u226530\u00a0kg\/m<jats:sup>2<\/jats:sup>, <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> mass normalized to height (2.7) (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.04, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0028), and <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.85, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0032) were associated with an increased risk of <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> followed by <jats:styled-content style=\"fixed-case\">EF<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 0.91, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.045), diabetes (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.91, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.065), and systolic blood pressure (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1.02, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.076).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results show that <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> is highly prevalent among obese subjects and impairment of longitudinal systolic mechanics, as reflected by <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content> reduction, and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> mass normalized to height are major independent predictors of <jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content> in this patients\u2019 population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13890","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T11:55:12Z","timestamp":1523966112000},"page":"1124-1131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Prevalence and determinants of left ventricular diastolic dysfunction in obese subjects and the role of left ventricular global longitudinal strain and mass normalized to height"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1458-4820","authenticated-orcid":false,"given":"Frank Lloyd","family":"Dini","sequence":"first","affiliation":[{"name":"Cardiovascular and Thoracic Department University of Pisa  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iacopo","family":"Fabiani","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department University of Pisa  Pisa 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