{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:25:00Z","timestamp":1740137100420,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In severe aortic stenosis, different left ventricle (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) remodeling patterns as a response to pressure overload have distinct hemodynamic profiles, cardiac function, and outcomes. The most common classification considers <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> relative wall thickness and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> mass index to create 4 different groups. A new classification including also end\u2010diastolic volume index has been recently proposed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe the prevalence of the newly identified remodeling patterns in patients with severe aortic stenosis and to evaluate their clinical relevance according to symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 286 consecutive patients with isolated severe aortic stenosis. Current guidelines were used for echocardiographic evaluation. Symptoms were defined as the presence of angina, syncope, or <jats:styled-content style=\"fixed-case\">NYHA<\/jats:styled-content> class <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 75\u00a0\u00b1\u00a09\u00a0years, 156 patients (54%) were men, while 158 (55%) were symptomatic. According to the new classification, the most frequent remodeling pattern was <jats:italic>concentric hypertrophy<\/jats:italic> (57.3%), followed by <jats:italic>mixed<\/jats:italic> (18.9%) and <jats:italic>dilated hypertrophy<\/jats:italic> (8.4%). There were no patients with <jats:italic>eccentric remodeling;<\/jats:italic> only 4 patients had a <jats:italic>normal<\/jats:italic><jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> geometry. Symptomatic patients showed significantly more <jats:italic>mixed hypertrophy<\/jats:italic> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), while the difference regarding the prevalence of the other patterns was not statistically significant. When we analyzed the distribution of the classic 4 patterns stratified by the presence of symptoms, however, we did not find a significant difference (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.157).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The new classification had refined the description of different cardiac geometric phenotypes that develop as a response to pressure overload. It might be superior to the classic 4 patterns in terms of association with symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13892","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T04:19:51Z","timestamp":1523938791000},"page":"1077-1084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["New classification of geometric ventricular patterns in severe aortic stenosis: Could it be clinically useful?"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8925-6149","authenticated-orcid":false,"given":"Concetta","family":"Di Nora","sequence":"first","affiliation":[{"name":"Cardiovascular Department ASUITS University of Trieste  Trieste Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Cervesato","sequence":"additional","affiliation":[{"name":"Santa Maria degli Angeli Hospital Cardiologia  Pordenone Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iulian","family":"Cosei","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Diseases \u201cProf. Dr. C. 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Iliescu\u201d  Bucharest Romania"},{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d  Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Zito","sequence":"additional","affiliation":[{"name":"Cardiology Department University of Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scipione","family":"Carerj","sequence":"additional","affiliation":[{"name":"Cardiology Department University of Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Antonini\u2010Canterin","sequence":"additional","affiliation":[{"name":"Rehabilitative Cardiology High Speciality Rehabilitative Hospital  Motta Di Livenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea C.","family":"Popescu","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d  Bucharest 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