{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:25:00Z","timestamp":1740137100387,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T00:00:00Z","timestamp":1524182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In aortic valve stenosis (AS), congestive heart failure (CHF) is a well\u2010established symptom that indicates the need for surgical aortic valve replacement (SAVR). However, it is difficult to judge whether CHF symptoms such as dyspnea are caused by severe AS or other conditions, especially in elderly persons with restricted mobility or other organ complications. It is important to identify objective and noninvasive parameters associated with severe CHF symptoms in severe AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred ninety\u2010eight patients with severe AS without left ventricular (LV) dysfunction were retrospectively studied. CHF symptoms were classified by New York Heart Association (NYHA) functional class. Echo parameters were compared between NYHA I\u2013III and NYHA IV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with NYHA IV (n\u00a0=\u00a040; 20%) were older (86\u00a0\u00b1\u00a06 vs 82\u00a0\u00b1\u00a08\u00a0years; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) and had a larger LV mass index (LVMI) (157\u00a0\u00b1\u00a043 vs 114\u00a0\u00b1\u00a034\u00a0g\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), a higher transmitral flow velocity ratio (E\/A) (1.31\u00a0\u00b1\u00a00.62 vs 0.93\u00a0\u00b1\u00a00.42; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), a shorter deceleration time (DT) (202\u00a0\u00b1\u00a072 vs 286\u00a0\u00b1\u00a098\u00a0ms; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and a higher systolic pulmonary arterial pressure (SPAP) (44\u00a0\u00b1\u00a013 vs 35\u00a0\u00b1\u00a013\u00a0mm\u00a0Hg; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) than patients with NYHA I\u2013III. On multivariable analysis, LVMI and DT were independently associated with NYHA IV. Receiver operating characteristic curve analysis identified LVMI\u00a0\u2265\u00a0142\u00a0g\/m<jats:sup>2<\/jats:sup> and DT\u00a0\u2264\u00a0194\u00a0ms as the cutoff values associated with NYHA IV in patients with severe AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Left ventricular mass index and DT were independently associated with severe heart failure (NYHA IV). These echo parameters could be helpful to judge whether CHF symptoms are caused by severe AS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.13895","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T11:07:05Z","timestamp":1524222425000},"page":"1108-1115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe heart failure (NYHA Class IV) is associated with increased left ventricular mass index and short mitral deceleration time in severe aortic valve stenosis"],"prefix":"10.1111","volume":"35","author":[{"given":"Sayuki","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Center of Medical Ultrasonics Saitama Medical Center Dokkyo Medical University  Saitama Japan"},{"name":"Department of Cardiology Saitama Medical Center Dokkyo Medical University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Applied Life Sciences Institute of Biomedical &amp; Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7172-8360","authenticated-orcid":false,"given":"Takahiro","family":"Shiota","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars\u2010Sinai Medical Center  Los Angeles CA USA"},{"name":"David Geffen School of Medicine University of California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.537"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs104"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.015"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2014.02.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90233-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.10.013"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000636"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.55.4.613"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4801.100076"},{"key":"e_1_2_6_12_1","first-page":"287","article-title":"Clinical factors associated with classical symptoms of aortic valve stenosis","volume":"22","author":"Nishizaki Y","year":"2013","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222203"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00407-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.116558"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(03)00092-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi290"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.5.2241"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.7.1933"},{"key":"e_1_2_6_20_1","first-page":"306","article-title":"Sustained favourable haemodynamics 1 year after TAVI: improvement in NYHA functional class related to improvement of left ventricular diastolic function","volume":"20","author":"Muratori M","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.973834"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx353"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.13895","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.13895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T10:38:22Z","timestamp":1694947102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.13895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,20]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/echo.13895"],"URL":"https:\/\/doi.org\/10.1111\/echo.13895","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"type":"print","value":"0742-2822"},{"type":"electronic","value":"1540-8175"}],"subject":[],"published":{"date-parts":[[2018,4,20]]},"assertion":[{"value":"2018-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}