{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:49:56Z","timestamp":1792180196461,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,10]],"date-time":"2018-06-10T00:00:00Z","timestamp":1528588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007172","name":"Cincinnati Children's Hospital Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In fetuses with structurally normal heart and suboptimal fetal growth (<jats:styled-content style=\"fixed-case\">SFG<\/jats:styled-content>), umbilical artery vascular resistance increases as measured by umbilical artery pulsatility index (<jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>). The objective of this study is to compare hemodynamic responses to <jats:styled-content style=\"fixed-case\">SFG<\/jats:styled-content> in fetuses with single ventricle (<jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>) and controls with structurally normal heart.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fetal echocardiograms around 30\u00a0weeks of gestation were reviewed. <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> and middle cerebral artery pulsatility index (<jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>) were calculated. <jats:styled-content style=\"fixed-case\">SFG<\/jats:styled-content> was defined as a birth weight below 25th percentile for gestational age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Studies from 92 fetuses were reviewed\u2014<jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content> (n\u00a0=\u00a050) and controls (n\u00a0=\u00a042). The prevalence of <jats:styled-content style=\"fixed-case\">SFG<\/jats:styled-content> was higher in <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content> compared to controls (46% vs 21%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). In patients with normal heart and <jats:styled-content style=\"fixed-case\">SFG<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> UAPI<\/jats:styled-content> was significantly higher than normal controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.003) suggesting increased placental vascular resistance. In <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">SFG<\/jats:styled-content> there was no difference in <jats:styled-content style=\"fixed-case\">UAPI<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content> without <jats:styled-content style=\"fixed-case\">SFG<\/jats:styled-content>. There was no difference in <jats:styled-content style=\"fixed-case\">MCA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The hemodynamic response to <jats:styled-content style=\"fixed-case\">SFG<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content> varies from fetuses with structurally normal heart. The mechanism of <jats:styled-content style=\"fixed-case\">SFG<\/jats:styled-content> and the placental pathology may be distinct in <jats:styled-content style=\"fixed-case\">SV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14047","type":"journal-article","created":{"date-parts":[[2018,6,10]],"date-time":"2018-06-10T11:30:28Z","timestamp":1528630228000},"page":"1378-1384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hemodynamic adaptation to suboptimal fetal growth in patients with single ventricle physiology"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3777-4822","authenticated-orcid":false,"given":"Tarek","family":"Alsaied","sequence":"first","affiliation":[{"name":"Boston Children\u2019s Hospital Boston Children\u2019s Heart Center  Boston MA USA"},{"name":"Cincinnati Children\u2019s Hospital Medical Center Children\u2019s Heart Institute  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Tseng","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center Children\u2019s Heart Institute  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"King","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology Cincinnati Children\u2019s Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice","family":"Hahn","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center Children\u2019s Heart Institute  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Divanovic","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center Children\u2019s Heart Institute  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounira","family":"Habli","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Cincinnati Children\u2019s Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Cnota","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center Children\u2019s Heart Institute  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.100"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2009.00369.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.07.047"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.61"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1161\/CIRCULATIONAHA.115.019089","article-title":"Congenital heart defects and indices of fetal cerebral growth in a nationwide cohort of 924 422 Liveborn Infants","volume":"133","author":"Matthiesen NB","year":"2016","journal-title":"Circulation"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181827bf4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.709717"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.01.022"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0913"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4268"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437597.44550.5d"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.12.1662"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2004.00485.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14881"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330202"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-015-1132-6"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.597900"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"e976","DOI":"10.1542\/peds.2006-2742","article-title":"National Birth Defects Prevention S. 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