{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:01:19Z","timestamp":1791838879222,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010153","name":"Korean Society of Echocardiography","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Purpose<\/jats:title>Recently, the diastolic strain rate (DSR<\/jats:styled-content>) utilizing speckle\u2010tracking echocardiography has been proposed as a novel parameter for left ventricular diastolic function. We aimed to present normal reference data for those in a large\u2010sized, selected group of healthy individuals.<\/jats:p><\/jats:sec>Methods<\/jats:title>The current study was a part of the N<\/jats:italic>ormal echO<\/jats:italic>cardiogR<\/jats:italic>aphic M<\/jats:italic>easurements in KoreA<\/jats:italic>n popuL<\/jats:italic>ation (NORMAL<\/jats:styled-content>), a prospective nationwide survey from 23 centers in Korea. We analyzed 447 subjects (age 48\u00a0\u00b1\u00a015\u00a0years, 234 females) without any history of cardiovascular disease and presented the early and late DSR<\/jats:styled-content>s (SR<\/jats:styled-content>e<\/jats:sub> and SR<\/jats:styled-content>a<\/jats:sub>, respectively) in a total and gender\u2010\/age\u2010specified groups.<\/jats:p><\/jats:sec>Results<\/jats:title>Among the total subjects, the mean SR<\/jats:styled-content>e<\/jats:sub> and SR<\/jats:styled-content>a<\/jats:sub> were 1.6\u00a0\u00b1\u00a00.4\u00a0S\u22121<\/jats:sup> and 0.8\u00a0\u00b1\u00a00.3\u00a0S\u22121<\/jats:sup>, respectively. With increasing age, there were significant trends of decreasing SR<\/jats:styled-content>e<\/jats:sub> and increasing SR<\/jats:styled-content>a<\/jats:sub>. Although both gender groups showed comparable age, the female group presented significantly higher SR<\/jats:styled-content>e<\/jats:sub> compared to male subjects with age of 20\u201359\u00a0years, which diminished after the age of 60\u00a0years. However, the SR<\/jats:styled-content>a<\/jats:sub> was comparable between genders in all age groups. On multiple linear regression, age showed independent associations with both SR<\/jats:styled-content>e<\/jats:sub> (\u03b2\u00a0=\u00a0\u22120.132, P<\/jats:italic>\u00a0=\u00a0.010) and SR<\/jats:styled-content>a<\/jats:sub> (\u03b2\u00a0=\u00a00.440, P<\/jats:italic>\u00a0<\u00a0.001), whereas gender did not show any association with SR<\/jats:styled-content>e<\/jats:sub> or SR<\/jats:styled-content>a<\/jats:sub>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We present normal reference data of a novel parameter, DSR<\/jats:styled-content>, in a large\u2010sized selected group with healthy Korean subjects. Additionally, we present significant age\u2010related changes both in SR<\/jats:styled-content>e<\/jats:sub> and SR<\/jats:styled-content>a<\/jats:sub> without the impact of their gender.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14053","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T17:26:45Z","timestamp":1529429205000},"page":"1533-1541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Normal reference values of diastolic strain rate in healthy individuals: Chronological trends and the comparison according to genders"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6019-4343","authenticated-orcid":false,"given":"Byung Joo","family":"Sun","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Chungnam National University Hospital Chungnam National University School of Medicine Daejeon 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Ok","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Rang","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Gyeongsang National University Hospital Gyeongsang National University School of Medicine Jinju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il Suk","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kyung Hee University School of Medicine Kyung Hee University Hospital at Gangdong Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungseop","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Keimyung University Dongsan Medical Center Daegu 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