{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T07:09:32Z","timestamp":1772348972303,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Background<\/jats:title>Cardiac shockwave therapy (CSWT<\/jats:styled-content>) is a new potential option for the treatment of patients with chronic coronary disease and refractory angina (RA<\/jats:styled-content>). We aimed to study the effects of CSWT<\/jats:styled-content> on left ventricular myocardial perfusion and mechanics in patients with RA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Method<\/jats:title>We prospectively studied 19 patients who underwent CSWT<\/jats:styled-content>. Left ventricular mechanics were evaluated by speckle tracking echocardiography (STE<\/jats:styled-content>), and myocardial perfusion by single\u2010photon emission computed tomography, using stress\/rest\u2013Technetium\u201099\u00a0m Sestamibi, for determination of summed stress score (SSS<\/jats:styled-content>). Canadian Cardiac Society (CCS<\/jats:styled-content>), New York Heart Association (NYHA<\/jats:styled-content>), and quality of life by Seattle Angina Questionnaire (SAQ<\/jats:styled-content>) were assessed at baseline and 6\u00a0months after therapy.<\/jats:p><\/jats:sec>Results<\/jats:title>CSWT<\/jats:styled-content> therapy was applied without major side effects. At baseline, 18 patients (94.7%) had CCS<\/jats:styled-content> class III<\/jats:styled-content> or IV<\/jats:styled-content>, and after CSWT<\/jats:styled-content> there was reduction to 3 (15.8%), P<\/jats:italic>\u00a0=\u00a0.0001, associated with improvement in SAQ<\/jats:styled-content> (38.5%; P<\/jats:italic>\u00a0<\u00a0.001). Thirteen (68.4%) had class NYHA III<\/jats:styled-content> or IV<\/jats:styled-content> before treatment, with significant reduction to 7 (36.8%); P<\/jats:italic>\u00a0=\u00a0.014. No change was observed in the global SSS<\/jats:styled-content> from baseline to 6\u2010month follow\u2010up (15.33\u00a0\u00b1\u00a08.60 vs 16.60\u00a0\u00b1\u00a08.06; P<\/jats:italic>\u00a0=\u00a0.157). However, there was a significant reduction in the average SSS<\/jats:styled-content> of the treated ischemic segments (2.1\u00a0\u00b1\u00a00.87 pre vs 1.6\u00a0\u00b1\u00a01.19 post CSWT<\/jats:styled-content>; P<\/jats:italic>\u00a0=\u00a0.024). Global longitudinal strain by STE<\/jats:styled-content> remained unaltered (\u201013.03\u00a0\u00b1\u00a08.96 pre vs \u201015.88\u00a0\u00b1\u00a03.43 6\u2010month post CSWT<\/jats:styled-content>; P<\/jats:italic>\u00a0=\u00a0.256).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>CSWT<\/jats:styled-content> is a safe procedure for the treatment of patients with RA<\/jats:styled-content> that results in better quality of life, improvement in myocardial perfusion of the treated segments with preservation of left ventricular mechanics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14054","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T06:49:03Z","timestamp":1530514143000},"page":"1564-1570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cardiac shock wave therapy improves myocardial perfusion and preserves left ventricular mechanics in patients with refractory angina: A study with speckle tracking echocardiography"],"prefix":"10.1111","volume":"35","author":[{"given":"Anderson S.","family":"Duque","sequence":"first","affiliation":[{"name":"Heart Institute (InCor) University of Sao Paulo Medical School Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conrado L.","family":"Ceccon","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) University of Sao Paulo Medical School Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Wilson","family":"Mathias","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) University of Sao Paulo Medical School Sao Paulo Brazil"},{"name":"Fleury Medicine and Health Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana Diniz","family":"Majesky","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) University of Sao Paulo Medical School Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis H.","family":"Gowdak","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) University of Sao Paulo Medical School Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o C. N.","family":"Sbano","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) University of Sao Paulo Medical School Sao Paulo Brazil"},{"name":"Fleury Medicine and Health Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Antonio Machado","family":"Cesar","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) University of Sao Paulo Medical School Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Abduch","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) University of Sao Paulo Medical School Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-2500","authenticated-orcid":false,"given":"M\u00e1rcio S. M.","family":"Lima","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) University of Sao Paulo Medical School Sao Paulo Brazil"},{"name":"Fleury Medicine and Health Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo M. M.","family":"Dourado","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) University of Sao Paulo Medical School Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia B. B. V.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) University of Sao Paulo Medical School Sao Paulo Brazil"},{"name":"Fleury Medicine and Health Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2449-0764","authenticated-orcid":false,"given":"Jeane M.","family":"Tsutsui","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) University of Sao Paulo Medical School Sao Paulo Brazil"},{"name":"Fleury Medicine and Health Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"e29","article-title":"Heart disease and stroke satatistics \u2013 2015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian D","year":"2015","journal-title":"Circulation"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2009.09.538"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.2706"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2014.10.011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2217\/ica.11.5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2008.00790.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00397-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102975"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nuclcard.2006.08.012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-200602000-00011"},{"key":"e_1_2_6_13_1","first-page":"140","article-title":"Acoustic cavitation: a possible consequence of biomedical uses of ultrasound","volume":"45","author":"Apfel RE","year":"1982","journal-title":"Br J Cancer Suppl"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-4177(02)00089-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02807-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(03)00104-9"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000148849.51177.97"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.3527"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024342"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12546"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20811"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e32834e4fa5"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-015-0853-0"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5922.2012.00313.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000000218"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.14054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T22:27:33Z","timestamp":1694903253000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.14054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/echo.14054"],"URL":"https:\/\/doi.org\/10.1111\/echo.14054","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"2018-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}