{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:42:28Z","timestamp":1784169748535,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007186","name":"Jonsson Comprehensive Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007186","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The left atrium (LA) modulates left ventricular filling pressure and is a strong prognosticator in heart failure. Although anthracycline exposure may lead to impaired left ventricular (LV) function, the effects on LA function are not well\u2010described in the younger population. We aim to evaluate LA function in children exposed to anthracyclines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children exposed to anthracyclines with pre\u2010 and post\u2010treatment echocardiographic imaging were enrolled. Measures of LA function (LA ejection fraction [LA EF], global longitudinal strain [GLS], and peak GLS rate) were quantified using 2D speckle tracking echocardiography pre\u2010 and post\u2010anthracycline therapy and were compared. Segments with poor tracking were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five children (age 13 [SD 5] years) treated with anthracyclines were evaluated. LA EF, GLS, and peak GLS rate were lower after anthracycline exposure. Mean changes were as follows: LA EF (pre\u201073.5 [SD 7.7]% vs post\u201070.6 [SD 8.2]%, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.06), GLS (\u221234.2 [SD 8.4]% vs \u221231.9 [SD 7.1]%, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.09), peak GLS rate (2.2 [SD 0.8]\u00a0s<jats:sup>\u22121<\/jats:sup> vs 2.0 [SD 0.6]\u00a0s<jats:sup>\u22121<\/jats:sup>, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.18). When stratified by pre\u2010 (\u226412\u00a0years old) vs post\u2010puberty (&gt;12\u00a0years old), prepubescent patients (n\u00a0=\u00a021) had statistically significant changes in pre\/post LA GLS (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01) and LA EF (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01). In models adjusted for radiation dose, age, gender, body surface area, or cumulative anthracycline dose, there were no significant relationships in the absolute difference between pre\/post LA EF (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.34) or LA GLS (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.18).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In children exposed to anthracyclines, short\u2010term effects on LA function were minimal in those with preserved LV EF. Age\u2010dependent LA susceptibility to anthracycline requires further study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14100","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T17:28:53Z","timestamp":1532712533000},"page":"1649-1656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Left atrial function in children and young adult cancer survivors treated with anthracyclines"],"prefix":"10.1111","volume":"35","author":[{"given":"Nisha R.","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Cardiology David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K.","family":"Chyu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Mattel Children's Hospital David Geffen School of Medicine at UCLA  Los Angeles California"},{"name":"Division of Pediatric Cardiology Benioff Children's Hospital University of California San Francisco  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M.","family":"Satou","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Mattel Children's Hospital David Geffen School of Medicine at UCLA  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Halnon","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Mattel Children's Hospital David Geffen School of Medicine at UCLA  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8854-2976","authenticated-orcid":false,"given":"Kim\u2010Lien","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Cardiology David Geffen School of Medicine at UCLA and VA Greater Los Angeles 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