{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:13:17Z","timestamp":1790363597800,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T00:00:00Z","timestamp":1532822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate aortic stiffness and subclinical left ventricular systolic dysfunction in ankylosing spondylitis (AS) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study of 55 <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients being treated with antitumor necrosis factor alpha (anti\u2013<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) biological agents, conventional synthetic disease\u2010modifying antirheumatic drugs (cs<jats:styled-content style=\"fixed-case\">DMARDS<\/jats:styled-content>), and non steroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s) and 20 controls matched for conventional cardiovascular risk factors. Aortic stiffness, ejection fraction, and left ventricular global longitudinal strain (<jats:styled-content style=\"fixed-case\">LVGLS<\/jats:styled-content>) were evaluated using transthoracic echocardiography and 2D Doppler echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Aortic stiffness was higher in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients when compared to controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009). Stiffness increased in those being treated with cs<jats:styled-content style=\"fixed-case\">DMARD<\/jats:styled-content>s when compared to the control group and those on anti\u2013<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 biologics (<jats:italic>P<\/jats:italic> \u02c20.001). <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients\u2019 <jats:styled-content style=\"fixed-case\">LVGLS<\/jats:styled-content> values were worse than those of the control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and also worse in patients on cs<jats:styled-content style=\"fixed-case\">DMARD<\/jats:styled-content>s and anti\u2013<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 biologics when compared to those being treated with <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Subclinical cardiac dysfunction occurs in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients despite well controlled musculoskeletal disease. Aortic stiffness and <jats:styled-content style=\"fixed-case\">LVGLS<\/jats:styled-content> increases in <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients. Anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> biological agents may somewhat protect arterial compliance. We believe that all <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> patients should be investigated for cardiac dysfunction and followed up accordingly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14103","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T03:34:03Z","timestamp":1532921643000},"page":"1579-1586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Subclinical cardiac disease in ankylosing spondylitis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7290-8558","authenticated-orcid":false,"given":"Selin","family":"Ozen","sequence":"first","affiliation":[{"name":"Department of Physical and Rehabilitation Medicine Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Ozen","sequence":"additional","affiliation":[{"name":"Department of 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