{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:21:18Z","timestamp":1782876078418,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hereditary haemochromatosis (<jats:styled-content style=\"fixed-case\">HH<\/jats:styled-content>) is a common inherited disease. Abnormally increased intestinal iron absorption and accelerated recycling of iron by macrophages lead to progressive body iron accumulation and the generation of oxidative stress. In the late stages, iron overload can lead to dysfunction of the left ventricle (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>). It is believed that two\u2010dimensional speckle tracking echocardiography (2D <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>) can evaluate <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> dysfunction more accurately than conventional echocardiography. This accurate evaluation seems to be clinically important in the early stages of <jats:styled-content style=\"fixed-case\">HH<\/jats:styled-content> before substantial damage of the <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>. Evaluation of this assessment was the purpose of this paper.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled 24 patients with early diagnosed <jats:styled-content style=\"fixed-case\">HH<\/jats:styled-content> and without any history of cardiovascular diseases; 23 healthy age\u2010 and sex\u2010matched volunteers constituted the control group. Standard echocardiographic parameters and <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> rotation and strain parameters were assessed and compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All echocardiographic parameters were within normal ranges, and there were no differences between the groups. 2D <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> revealed significantly worse basal and apical rotation, twist and torsion values in <jats:styled-content style=\"fixed-case\">HH<\/jats:styled-content> patients. The peak systolic longitudinal strain was decreased in <jats:styled-content style=\"fixed-case\">HH<\/jats:styled-content> patients, even though the <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>) was normal. There were weak correlations between the iron turnover and 2D <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>2D <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content> seems to be more sensitive than traditional echocardiography for detecting <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> abnormalities in <jats:styled-content style=\"fixed-case\">HH<\/jats:styled-content> patients who are diagnosed early. The results of this study may be clinically useful, but their relevance and therapeutic implications remain to be confirmed by further studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14141","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:39:36Z","timestamp":1537922376000},"page":"1772-1781","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Can two\u2010dimensional speckle tracking echocardiography be useful for left ventricular assessment in the early stages of hereditary haemochromatosis?"],"prefix":"10.1111","volume":"35","author":[{"given":"Katarzyna","family":"Rozwadowska","sequence":"first","affiliation":[{"name":"Clinical Centre of Cardiology University Clinical Centre  Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2269-1880","authenticated-orcid":false,"given":"Ludmi\u0142a","family":"Dani\u0142owicz\u2010Szymanowicz","sequence":"additional","affiliation":[{"name":"II Department of Cardiology and Electrotherapy Medical University of Gdansk  Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Fija\u0142kowski","sequence":"additional","affiliation":[{"name":"I Department of Cardiology Medical University of Gdansk  Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Sikorska","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine and Epidemiology Medical University of Gdansk  Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Ga\u0142\u0105ska","sequence":"additional","affiliation":[{"name":"I Department of Cardiology Medical University of Gdansk  Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Koz\u0142owski","sequence":"additional","affiliation":[{"name":"II Department of Cardiology and Electrotherapy Medical University of Gdansk  Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Grucha\u0142a","sequence":"additional","affiliation":[{"name":"I Department of Cardiology Medical University of Gdansk  Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Raczak","sequence":"additional","affiliation":[{"name":"II Department of Cardiology and Electrotherapy Medical University of Gdansk  Gdansk Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0b013e3182a67805"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805263182103"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21913"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-399"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.34.4.275"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.06.045"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb55510.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511143132004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(79)90390-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(71)90240-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.16.1835"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00903-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.11.1302"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(83)90422-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mje.2002.118032"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14017430802203811"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-008-9383-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb55509.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00005792-195512000-00001","article-title":"Idiopathic hemochromatosis, an iron storage disease. 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