{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:14:13Z","timestamp":1790338453788,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Background<\/jats:title>Nonagenarians (NON<\/jats:styled-content>) are a growing segment of the population and have a high prevalence of cardiac disease. Many findings encountered on their echocardiograms are also found in younger individuals with valvular or myocardial disease. Therefore, the purpose of this study was to describe this distinct echocardiographic phenotype.<\/jats:p><\/jats:sec>Methods<\/jats:title>We identified our study population by querying our echo database to identify unique septuagenarians (SEPT<\/jats:styled-content>) and nonagenarians (NON<\/jats:styled-content>) who underwent a transthoracic echocardiogram (TTE<\/jats:styled-content>) from January 1, 2010 to December 31, 2014. Exclusion criteria were LVEF<\/jats:styled-content>\u00a0<\u00a050%, any akinetic wall segment, aortic stenosis, moderate\u2010severe AR<\/jats:styled-content> and\/or severe MR<\/jats:styled-content>, coronary revascularization within 60\u00a0days of study echo, and prior valve surgery.<\/jats:p><\/jats:sec>Results<\/jats:title>The mean age of SEPT<\/jats:styled-content> was 73.0\u00a0\u00b1\u00a02.0 and NON<\/jats:styled-content> was 92.0\u00a0\u00b1\u00a02.1 (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001). There was no gender difference between groups. NON<\/jats:styled-content> had significantly smaller LV<\/jats:styled-content> end\u2010diastolic diameters than SEPT<\/jats:styled-content> (41.6\u00a0\u00b1\u00a05.7\u00a0mm vs 48.0\u00a0\u00b1\u00a07.0\u00a0mm, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001). NON<\/jats:styled-content> had a greater relative wall thickness (0.51\u00a0\u00b1\u00a00.10 vs 0.40\u00a0\u00b1\u00a00.08, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001) and more frequently had concentric remodeling or hypertrophy. NON<\/jats:styled-content> had higher E\/Ea ratios and estimated LA<\/jats:styled-content> pressures (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01). 48% of NON<\/jats:styled-content> had moderate\u2010severe mitral annular calcification compared to 25.0% of SEPT<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Herein, we provide the first comprehensive echocardiographic description of \u2018presbycardia'; concentric LVH<\/jats:styled-content>, asymmetric septal hypertrophy, mitral and aortic valve calcification, and increased epicardial fat thickness. This pattern of findings may be increasingly seen as the population ages.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14160","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T19:19:08Z","timestamp":1542309548000},"page":"1974-1981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The presbycardia phenotype: Cardiac remodeling and valvular degeneration in nonagenarians"],"prefix":"10.1111","volume":"35","author":[{"given":"Aline","family":"Iskandar","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Mowakeaa","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Sardana","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0229-034X","authenticated-orcid":false,"given":"Timothy P.","family":"Fitzgibbons","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis A.","family":"Tighe","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Parker","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Kakouros","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McManus","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Medicine University of Massachusetts Medical School Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4746-9669","authenticated-orcid":false,"given":"Gerard P.","family":"Aurigemma","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department 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