{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:06:01Z","timestamp":1770815161036,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Background<\/jats:title>Left ventricular (LV<\/jats:styled-content>) remodeling due to aortic regurgitation (AR<\/jats:styled-content>) often leads to maladaptive responses. We assessed the prevalence and clinical implications of LV<\/jats:styled-content> remodeling considering LV<\/jats:styled-content> volume, mass, and relative wall thickness at the time of AR<\/jats:styled-content> diagnosis.<\/jats:p><\/jats:sec>Methods and Results<\/jats:title>Between 2008 and 2017, 370 consecutive patients (mean age 67.3\u00a0\u00b1\u00a016.1\u00a0years, 56.5% males), with moderate or severe AR<\/jats:styled-content>, were retrospectively analyzed. LV<\/jats:styled-content> geometric patterns and clinical outcomes (cardiovascular death, hospitalization for heart failure, or aortic valve replacement) were evaluated. LV<\/jats:styled-content> dilatation (LV<\/jats:styled-content> end\u2010diastolic volume >75\u00a0mL\/m2<\/jats:sup>) was present in 228 patients (61.6%). Applying the new LV<\/jats:styled-content> remodeling classification system, 40 (10.8%) patients had normal geometry, 14 (3.8%) concentric remodeling, 43 (11.6%) concentric hypertrophy (LVH<\/jats:styled-content>), 45 (12.2%) indeterminate LVH<\/jats:styled-content>, 38 (10.3%) mixed LVH<\/jats:styled-content>, 93 (25.1%) dilated LVH<\/jats:styled-content>, 54 (14.6%) eccentric LVH<\/jats:styled-content>, and 43 (11.6%) eccentric remodeling. During a median follow\u2010up of 3.48\u00a0years (25th\u201375th percentile 0.91\u20135.57), 97 (26.2%) had the combined endpoint. LV<\/jats:styled-content> dilation (P<\/jats:italic>\u00a0<\u00a00.001), LVH<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.001), and LV<\/jats:styled-content> remodeling patterns were significantly associated with the combined endpoint. After multivariable adjustment for age, EF<\/jats:styled-content>, aortic stenosis, CAD<\/jats:styled-content> history, and moderate mitral regurgitation, dilated LVH<\/jats:styled-content> (HR<\/jats:styled-content> 7.61, IC<\/jats:styled-content> 95% 1.82\u201331.80; P<\/jats:italic>\u00a0=\u00a00.005) and eccentric LVH<\/jats:styled-content> (HR<\/jats:styled-content> 7.91, IC<\/jats:styled-content> 95% 1.82\u201334.38; P<\/jats:italic>\u00a0=\u00a00.006) were associated with adverse outcome compared to eccentric remodeling, that showed the best event\u2010free survival rate.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In a contemporary cohort of patients with AR<\/jats:styled-content>, applying the new LV<\/jats:styled-content> remodeling classification system, only a minority had normal geometry. Dilated LVH<\/jats:styled-content> and eccentric LVH<\/jats:styled-content> showed distinct outcome penalty after adjustment for confounders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14190","type":"journal-article","created":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T13:56:22Z","timestamp":1541685382000},"page":"38-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["New classification of geometric patterns considering left ventricular volume in patients with chronic aortic valve regurgitation: Prevalence and association with adverse cardiovascular outcomes"],"prefix":"10.1111","volume":"36","author":[{"given":"Andrea","family":"Barbieri","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Diagnostics, Clinical and Public Health Medicine Policlinico University Hospital of Modena University of Modena and Reggio Emilia Modena 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Cardiology San Paolo Hospital Heart and Lung Department ASST Santi Paolo and Carlo University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3215-9388","authenticated-orcid":false,"given":"Marcella","family":"Manicardi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Diagnostics, Clinical and Public Health Medicine Policlinico University Hospital of Modena University of Modena and Reggio Emilia Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Boriani","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Diagnostics, Clinical and Public Health Medicine Policlinico University Hospital of Modena University of Modena and Reggio Emilia Modena 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