{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:34:48Z","timestamp":1787168088084,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010167","name":"Shanghai Shen Kang Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC22015019"],"award-info":[{"award-number":["SHDC22015019"]}],"id":[{"id":"10.13039\/501100010167","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Challenges remain in quantitative evaluation of right ventricular (\n                      <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n                      ) function by echocardiography. Multiple\u2010view assessment is believed to provide a more comprehensive quantification of\n                      <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n                      function than conventional single\u2010view analysis. Peak systolic longitudinal\n                      <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n                      strain (\n                      <jats:styled-content style=\"fixed-case\">RVLS<\/jats:styled-content>\n                      ) measured by speckle tracking echocardiography (\n                      <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>\n                      ) has clinical and prognostic value. No study has investigated\n                      <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n                      systolic function in the repaired tetralogy of Fallot (rTOF) using a standardized four\u2010view iRotate model from one apical view. Herein, we examined the feasibility and accuracy of the four\u2010view analysis from apical window in quantitation of\n                      <jats:styled-content style=\"fixed-case\">RVLS<\/jats:styled-content>\n                      among children with rTOF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010seven children with rTOF and 37 age\u2010 and gender\u2010matched controls were prospectively enrolled. Tricuspid annular plane systolic excursion (\n                      <jats:styled-content style=\"fixed-case\">TAPSE<\/jats:styled-content>\n                      ) and tricuspid annular peak systolic velocity (\n                      <jats:styled-content style=\"fixed-case\">TDI<\/jats:styled-content>\n                      \u2010S\n                      <jats:sup>\u2032<\/jats:sup>\n                      ) and fractional area change(\n                      <jats:styled-content style=\"fixed-case\">FAC<\/jats:styled-content>\n                      ) were obtained.\n                      <jats:styled-content style=\"fixed-case\">RVLS<\/jats:styled-content>\n                      of four free\u2010walls were analyzed by dedicated\n                      <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n                      speckle tracking software. Echocardiographic parameters were compared with the right ventricular ejection fraction (\n                      <jats:styled-content style=\"fixed-case\">RVEF<\/jats:styled-content>\n                      ) measured by the cardiac magnetic resonance (\n                      <jats:styled-content style=\"fixed-case\">CMR<\/jats:styled-content>\n                      ) in children with\n                      <jats:styled-content style=\"fixed-case\">rTOF<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multi\u2010view\n                      <jats:styled-content style=\"fixed-case\">RVLS<\/jats:styled-content>\n                      analysis from apical window was feasible in 35 children with\n                      <jats:styled-content style=\"fixed-case\">rTOF<\/jats:styled-content>\n                      and all the controls. Compared with age\u2010 and gender\u2010matched controls,\n                      <jats:styled-content style=\"fixed-case\">RVLS<\/jats:styled-content>\n                      of the anterior, lateral, inferior\u2010a, and inferior\u2010b walls were significantly reduced in children with\n                      <jats:styled-content style=\"fixed-case\">rTOF<\/jats:styled-content>\n                      (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.001).\n                      <jats:styled-content style=\"fixed-case\">RVLS<\/jats:styled-content>\n                      of the anterior, lateral, inferior\u2010a, and inferior\u2010b walls correlated well with\n                      <jats:styled-content style=\"fixed-case\">CMR<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">RVEF<\/jats:styled-content>\n                      in children with\n                      <jats:styled-content style=\"fixed-case\">rTOF<\/jats:styled-content>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.667, \u22120.743, \u22120.808, \u22120.695,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Multi\u2010view analysis of\n                      <jats:styled-content style=\"fixed-case\">RVLS<\/jats:styled-content>\n                      from apical window can be applied to evaluate the\n                      <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n                      function in children with\n                      <jats:styled-content style=\"fixed-case\">rTOF<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">RVLS<\/jats:styled-content>\n                      of the inferior wall\u2010a in the aortic view is a novel and accurate indicator of\n                      <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\n                      function because of its good reproducibility and strong correlation with\n                      <jats:styled-content style=\"fixed-case\">CMR<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">RVEF<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  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