{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T20:04:52Z","timestamp":1782245092884,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the impact of baseline left ventricular ejection fraction (LVEF) and its interaction with low\u2010gradient aortic stenosis (LGAS) on all\u2010cause mortality after transfemoral aortic valve implantation (TF\u2010TAVI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed mortality data of 624 consecutive single center TF\u2010TAVI patients and categorized LVEF according to current ASE\/EACVI recommendations (normal, mildly\u2010, moderately\u2010, and severely abnormal).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline LVEF was normal in 336 (53.8%), mildly abnormal in 160 (25.6%), moderately abnormal in 91 (14.6%), and severely abnormal in 37 (5.9%) patients, and 1\u2010year mortality was 19%, 17%, 23%, and 43% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002), respectively. Patients with LGAS had a similar 1\u2010year mortality compared to those without LGAS in groups with normal (19% vs 19%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.899) and mildly abnormal LVEF (16% vs 17%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.898). One\u2010year mortality of patients with LGAS was significantly greater than in those without LGAS in presence of moderately abnormal LVEF (31% vs 11%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.022), and it was numerically greater than in those without LGAS in presence of severely abnormal LVEF (48% vs 25%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.219). In multivariate analysis, only the combination of moderately\/severely abnormal LVEF and LGAS predicted increased 1\u2010year mortality (HR: 2.12, 95% CI: 1.4\u20133.2, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Other variables, including EuroSCORE I did not affect this result.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Moderately\/severely abnormal LVEF (\u226440%) at baseline is associated with increased mortality after TF\u2010TAVI, especially when the mean transvalvular aortic gradient is &lt;40\u00a0mm\u00a0Hg (LGAS), while outcomes in patients with normal and mildly abnormal LVEF are comparable regardless of the pressure gradient across the native aortic valve. (DRKS00013729).<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14203","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T16:24:15Z","timestamp":1543422255000},"page":"28-37","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of baseline left ventricular ejection fraction on outcome after transfemoral transcatheter aortic valve implantation in patients with and without low\u2010gradient aortic stenosis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9919-409X","authenticated-orcid":false,"given":"Karim","family":"El\u2010Chilali","sequence":"first","affiliation":[{"name":"Department of Cardiology and Vascular Medicine West\u2010German Heart and Vascular Center Essen Essen University Hospital Duisburg\u2010Essen University  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polykarpos Christos","family":"Patsalis","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine West\u2010German Heart and Vascular Center Essen Essen University Hospital Duisburg\u2010Essen University  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Al\u2010Rashid","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine West\u2010German Heart and Vascular Center Essen Essen University Hospital Duisburg\u2010Essen University  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike Annelie","family":"Kahlert","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Vascular Medicine West\u2010German Heart and Vascular Center Essen Essen University Hospital Duisburg\u2010Essen University  Essen 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