{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:10:41Z","timestamp":1784589041377,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Carotid intima\u2010media thickness (CIMT) is an established surrogate marker for cardiovascular events in patients with intermediate risk. In patients with high cardiovascular risk or established cardiovascular disease, the impact of CMIT measurement on risk stratification for future events is less clear. Our objective was to evaluate the impact of CIMT on the occurrence of cardiovascular events in a cohort of individuals with high cardiovascular risk, in long\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 296 individuals, mean follow\u2010up of 6.9\u00a0\u00b1\u00a02.2\u00a0years. Individuals were divided into tertiles according to CIMT. Tertiles were compared in terms of baseline characteristics and outcomes during follow\u2010up\u2014all\u2010cause mortality and composite outcome (mortality, acute coronary syndromes, coronary revascularization, stroke\/transient ischemic attack, heart failure, or cardiovascular admission).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our population had a mean age of 65\u00a0\u00b1\u00a09\u00a0years at the beginning of the study, 55% males. Patients with higher CIMT showed a trend for higher cardiovascular mortality (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.084) and for the composite outcome (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.049). A CIMT\u00a0\u2265\u00a00.85\u00a0mm was also associated with higher rate of events; however, CIMT was not an independent predictor of outcome after adjustment for age and gender. CIMT assessment was useful in patients with hypertension, hyperlipidemia, and metabolic syndrome and in nondiabetic patients. For the composite outcome, it was also useful in females, smokers, and in patients without coronary artery disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with higher CIMT have worst outcome, but this was mainly driven by age and gender. CIMT is useful as a prognostic marker in specific subsets of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14207","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T05:59:04Z","timestamp":1543298344000},"page":"125-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Has carotid intima\u2010media thickness prognostic impact in patients with high cardiovascular risk? A long\u2010term cohort study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6061-9663","authenticated-orcid":false,"given":"Ana Teresa","family":"Tim\u00f3teo","sequence":"first","affiliation":[{"name":"Cardiology Department Santa Marta Hospital Centro Hospitalar Universit\u00e1rio de Lisboa Central  Lisbon Portugal"},{"name":"Centro de Estudos de Doen\u00e7as Cr\u00f3nicas (CEDOC) NOVA Medical School  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Mota Carmo","sequence":"additional","affiliation":[{"name":"Cardiology Department Santa Marta Hospital Centro Hospitalar Universit\u00e1rio de Lisboa Central  Lisbon Portugal"},{"name":"Centro de Estudos de Doen\u00e7as Cr\u00f3nicas (CEDOC) NOVA Medical School  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Soares","sequence":"additional","affiliation":[{"name":"Cardiology Department Santa Marta Hospital Centro Hospitalar Universit\u00e1rio de Lisboa Central  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui Cruz","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Cardiology Department Santa Marta Hospital Centro Hospitalar Universit\u00e1rio de Lisboa Central  Lisbon Portugal"},{"name":"Centro de Estudos de Doen\u00e7as Cr\u00f3nicas (CEDOC) NOVA Medical School  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32152-9"},{"key":"e_1_2_7_3_1","unstructured":"World Health Organization (WHO).The top 10 causes of death. 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