{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:00:08Z","timestamp":1747184408566,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,3]]},"abstract":"Objectives<\/jats:title>The study aimed to assess the accuracy and reproducibility of the high\u2010definition blood flow imaging (HD<\/jats:styled-content>\u2010Flow) in evaluation of left ventricular (LV<\/jats:styled-content>) function by comparison with contrast echocardiography (Contrast).<\/jats:p><\/jats:sec>Background<\/jats:title>Contrast improves endocardial border visualization and assists in precise assessment of LV<\/jats:styled-content> function. HD<\/jats:styled-content>\u2010Flow, a novel ultrasound technique that enhances blood flow discrimination in LV<\/jats:styled-content>, could possibly be used for improving endocardial border definition without contrast.<\/jats:p><\/jats:sec>Methods<\/jats:title>Eighty patients with technically limited transthoracic echocardiograms had HD<\/jats:styled-content>\u2010Flow, and contrast performed sequentially. LV<\/jats:styled-content> endocardial visualization, image acquisition time, wall motion, volumes, ejection fraction (EF<\/jats:styled-content>), stroke volume (SV<\/jats:styled-content>), and stroke volume index (SVI<\/jats:styled-content>) were compared. Inter\u2010 and intra\u2010observer agreements were examined in a randomly selected subgroup.<\/jats:p><\/jats:sec>Results<\/jats:title>Both HD<\/jats:styled-content>\u2010Flow and contrast significantly improved the percentage of the well\u2010defined endocardial border segments (71% at baseline vs 94.1% by HD<\/jats:styled-content>\u2010Flow vs 94.9% by contrast, X<\/jats:italic>2<\/jats:sup>\u00a0=\u00a0401, P<\/jats:italic>\u00a0<\u00a00.001). The acquisition time for HD<\/jats:styled-content>\u2010Flow was significantly less when compared to contrast (2.13\u00a0\u00b1\u00a01.18\u00a0minutes vs 10.96\u00a0\u00b1\u00a03.51\u00a0minutes, P<\/jats:italic>\u00a0<\u00a00.001). LV<\/jats:styled-content> end\u2010diastolic volume (EDV<\/jats:styled-content>), end\u2010systolic volume (ESV<\/jats:styled-content>), EF<\/jats:styled-content>, SV<\/jats:styled-content>, and SVI<\/jats:styled-content> measured by the two methods correlated well (EDV<\/jats:styled-content>r\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.97, ESV<\/jats:styled-content>r\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.96, EF<\/jats:styled-content>r\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.90, SV<\/jats:styled-content>r\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.77, SVI<\/jats:styled-content>r\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.74, all P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001). In comparison, HD<\/jats:styled-content>\u2010Flow was neither significantly different in detecting LV<\/jats:styled-content> wall motion abnormality nor in EF<\/jats:styled-content>, SV<\/jats:styled-content>, and SVI<\/jats:styled-content> measurements, but slightly underestimated LV<\/jats:styled-content> volumes.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>HD<\/jats:styled-content>\u2010Flow imaging is feasible and user\u2010friendly in enhancing LV<\/jats:styled-content> endocardial definition. This technique is useful in both qualitative and quantitative assessment of LV<\/jats:styled-content> function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14282","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T22:22:34Z","timestamp":1550701354000},"page":"546-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["High\u2010definition blood flow imaging in the assessment of left ventricular function: Initial experience and comparison with contrast echocardiography"],"prefix":"10.1111","volume":"36","author":[{"given":"Geru","family":"Wu","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine University of Texas Medical Branch Galveston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianrong","family":"Xie","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine University of Texas Medical Branch Galveston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meneleo M.","family":"Dimaano","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine University of Texas Medical Branch Galveston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad I.","family":"Alghrouz","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine University of Texas Medical Branch Galveston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-7787","authenticated-orcid":false,"given":"Masood","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine University of Texas Medical Branch Galveston 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