{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:17:49Z","timestamp":1783117069690,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,4]]},"abstract":"Background<\/jats:title>Application of speckle\u2010tracking echocardiography (STE<\/jats:styled-content>) provides rapid assessment of tissue\u2010tracking mitral annular displacement (TMAD<\/jats:styled-content>). We investigated the value of TMAD<\/jats:styled-content> for the assessment of decreased LV<\/jats:styled-content> longitudinal deformation in asymptomatic patients with severe or moderate\u2010to\u2010severe mitral regurgitation (MR<\/jats:styled-content>) and preserved LV<\/jats:styled-content> ejection fraction (LVEF<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We retrospectively studied 50 patients with severe or moderate\u2010to\u2010severe organic MR<\/jats:styled-content> and preserved LVEF<\/jats:styled-content> (>60%) in whom global longitudinal strain (GLS<\/jats:styled-content>) was successfully measured by STE<\/jats:styled-content>. TMAD<\/jats:styled-content> was quickly assessed in the apical four\u2010chamber view using STE<\/jats:styled-content>. We calculated the percentage of TMAD<\/jats:styled-content> to LV<\/jats:styled-content> length from the midpoint of mitral annulus to the apex at end\u2010diastolic (%TMAD<\/jats:styled-content>). The study population was divided into two groups: decreased GLS<\/jats:styled-content> patients (>\u221220%; Group A) and preserved GLS<\/jats:styled-content> patients (\u2264\u221220%; Group B). We examined whether %TMAD<\/jats:styled-content> could be used as a diagnostic factor of decreased GLS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>%TMAD<\/jats:styled-content> was significantly lower in Group A than Group B (12.5\u00a0\u00b1\u00a00.5 vs 16.8\u00a0\u00b1\u00a02.2, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.0001). By univariate logistic regression analysis, %TMAD<\/jats:styled-content> was a diagnostic factor of decreased GLS<\/jats:styled-content>. By multiple regression analysis, %TMAD<\/jats:styled-content> remained an independent diagnostic factor of decreased GLS<\/jats:styled-content> (Odds ratio [OR<\/jats:styled-content>]\u00a0=\u00a04.21, 95% confidence interval [CI<\/jats:styled-content>]\u00a0=\u00a01.34\u201328.94, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.0001). A cutoff value of %TMAD<\/jats:styled-content> <14.6 had a sensitivity of 94% and specificity of 94% for the presence of decreased GLS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Tissue\u2010tracking mitral annular displacement is useful in the assessment of decreased LV<\/jats:styled-content> longitudinal deformation in asymptomatic patients with severe or moderate\u2010to\u2010severe MR<\/jats:styled-content> and preserved LVEF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14290","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T02:32:06Z","timestamp":1550543526000},"page":"678-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Assessment of decreased left ventricular longitudinal deformation in asymptomatic patients with organic mitral regurgitation and preserved ejection fraction using tissue\u2010tracking mitral annular displacement by speckle\u2010tracking echocardiography"],"prefix":"10.1111","volume":"36","author":[{"given":"Ikuko","family":"Teraguchi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6027-9053","authenticated-orcid":false,"given":"Takeshi","family":"Hozumi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Kashiwagi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Shimamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutsugu","family":"Shiono","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Kuroi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Wakayama Medical University Wakayama 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