{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:24:33Z","timestamp":1792409073251,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The differentiation between dilated cardiomyopathy (\n                      <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                      ) and systolic dysfunction caused by coronary artery disease (\n                      <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n                      ) based on clinical and echocardiographic presentation can be difficult in some cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Our study aimed to define differences in myocardial function between patients with ischemic and nonischemic etiology of reduced left ventricular ejection fraction using 2D speckle tracking echocardiography (\n                      <jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 90 patients (mean age 65\u00a0\u00b1\u00a011\u00a0years, 70% male) with de novo diagnosed reduced left ventricular ejection fraction (\u226445% as determined by the transthoracic echocardiography), who were referred for coronary angiography to determine the presence of significant\n                      <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n                      . On the basis of coronary angiography results, patients were divided into two subgroups as follows: 45 subjects with significant\n                      <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n                      (group A) and 45 subjects without\n                      <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n                      (group B). Acquired transthoracic echocardiographic images were assessed off\u2010line using 2\n                      <jats:styled-content style=\"fixed-case\">DSTE<\/jats:styled-content>\n                      . In each patient, we calculated arithmetic mean, median value, and standard deviation of regional longitudinal strain and strain rate of 18 left ventricular segments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Standard deviation of the regional peak early diastolic strain rate was significantly higher in group A than in group B (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01). The cutoff value with the highest diagnostic value was &gt;0.37\/s\u2014its sensitivity and specificity for the diagnosis of\n                      <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n                      were 73% and 53%, respectively. The remaining parameters did not differ significantly between the study groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Patients with systolic dysfunction resulting from\n                      <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n                      have significantly more heterogeneous regional longitudinal early diastolic strain rate assessed by 2\n                      <jats:styled-content style=\"fixed-case\">DSTE<\/jats:styled-content>\n                      than patients with\n                      <jats:styled-content style=\"fixed-case\">DCM<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  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