{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:00:15Z","timestamp":1747184415005,"version":"3.40.5"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T00:00:00Z","timestamp":1555632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Few studies have examined the effect of transmurality of myocardial necrosis on coronary microcirculation. The aim of this study was to examine the influence of cardiac magnetic resonance\u2010derived (GE<\/jats:styled-content>\u2010MRI<\/jats:styled-content>) structural determinants of coronary flow reserve (CFR<\/jats:styled-content>) after anterior myocardial infarction (STEMI<\/jats:styled-content>), and their predictive value on regional functional recovery.<\/jats:p><\/jats:sec>Methods<\/jats:title>Noninvasive CFR<\/jats:styled-content> and GE<\/jats:styled-content>\u2010MRI<\/jats:styled-content> were studied in 37 anterior STEMI<\/jats:styled-content> patients after primary coronary angioplasty. The wall motion score index in the left descending anterior coronary artery territory (A\u2010WMSI<\/jats:styled-content>) was calculated at admission and follow\u2010up (FU<\/jats:styled-content>). Recovery of regional left ventricular (LV<\/jats:styled-content>) function was defined as the difference in A\u2010WMSI<\/jats:styled-content> at admission and FU<\/jats:styled-content>. The necrosis score index (NSI<\/jats:styled-content>) and transmurality score index (TSI<\/jats:styled-content>) by GE<\/jats:styled-content>\u2010MRI<\/jats:styled-content> were calculated in the risk area. Baseline (BMR<\/jats:styled-content>) and hyperemic (HMR<\/jats:styled-content>) microvascular resistance, arteriolar resistance index (ARI<\/jats:styled-content>), and coronary resistance reserve (CRR<\/jats:styled-content>) were calculated at the Doppler echocardiography.<\/jats:p><\/jats:sec>Results<\/jats:title>Bivariate analysis indicated that the CPK<\/jats:styled-content> and troponin I peak, heart rate, NSI<\/jats:styled-content>, TSI<\/jats:styled-content>, BMR<\/jats:styled-content>, the ARI<\/jats:styled-content>, and CRR<\/jats:styled-content> were related to CFR<\/jats:styled-content>. Multivariable analysis revealed that TSI<\/jats:styled-content> was the only independent determinant of CFR<\/jats:styled-content>. The CFR<\/jats:styled-content> value of >2.27, identified as optimal by ROC<\/jats:styled-content> analysis, was 77% specific and 73% sensitive with accuracy of 76% in identifying patients with functional recovery.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Preservation of microvascular function after AMI<\/jats:styled-content> is related to the extent of transmurality of myocardial necrosis, is an important factor influencing regional LV<\/jats:styled-content> recovery, and can be monitored by noninvasive CFR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14337","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T10:24:42Z","timestamp":1555669482000},"page":"844-853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Coronary flow reserve is related to the extension and transmurality of myocardial necrosis and predicts functional recovery after acute 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