{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:00:38Z","timestamp":1760122838289,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T00:00:00Z","timestamp":1555632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Background<\/jats:title>Left atrial spontaneous echo contrast (SEC<\/jats:styled-content>) is an existence of smoke\u2010like echoes with a typical swirling motion of blood in left atrial cavity or appendage, and it is known to be a marker of prothrombotic state. Previous studies have revealed that there is an association between prothrombotic state and the platelet\u2010to\u2010lymphocyte ratio (PLR<\/jats:styled-content>). Thus, we aimed to investigate the association between the presence of SEC<\/jats:styled-content> and PLR<\/jats:styled-content> in patients with mitral stenosis (MS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 306 consecutive patients with MS<\/jats:styled-content> were enrolled in the study. Transoesophageal echocardiography was made to assess the SEC<\/jats:styled-content> for all patients. Recruited patients were divided into two groups according to the formation of SEC<\/jats:styled-content> in the left atrium. Complete blood counting parameters, biochemical tests and high\u2010sensitive C\u2010reactive protein (Hs\u2010CRP<\/jats:styled-content>) levels were measured.<\/jats:p><\/jats:sec>Results<\/jats:title>There were 182 patients (mean age 42.7\u00a0\u00b1\u00a011.9 and 78% female) in the SEC<\/jats:styled-content> (\u2212) group, and 124 patients (mean age 45.3\u00a0\u00b1\u00a010.5 and 68% female) in the SEC<\/jats:styled-content> (+) group. Hs\u2010CRP<\/jats:styled-content> levels (3.9\u00a0\u00b1\u00a01.9 vs 5.1\u00a0\u00b1\u00a03.6, P<\/jats:italic>\u00a0<\u00a00.001) were significantly different between the two groups. PLR<\/jats:styled-content> (143.4\u00a0\u00b1\u00a077.7 vs 180.6\u00a0\u00b1\u00a0108.7, P<\/jats:italic>\u00a0<\u00a00.001) was significantly higher in the SEC<\/jats:styled-content> (+) group. ROC<\/jats:styled-content> curve analysis, PRL<\/jats:styled-content> \u2265123 had 71% sensitivity and 52% specificity in predicting SEC<\/jats:styled-content> in patients with MS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Platelet\u2010to\u2010lymphocyte ratio is an inexpensive and easily calculated biomarker, which is useful to predict left atrial SEC<\/jats:styled-content> in patients with mitral stenosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14338","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T10:34:03Z","timestamp":1555670043000},"page":"924-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Relationship between presence of spontaneous echo contrast and platelet\u2010to\u2010lymphocyte ratio in patients with mitral stenosis"],"prefix":"10.1111","volume":"36","author":[{"given":"Omer","family":"Sahin","sequence":"first","affiliation":[{"name":"Department of Cardiology Kayseri Training and Research Hospital Kayseri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7086-2157","authenticated-orcid":false,"given":"Goktug","family":"Savas","sequence":"additional","affiliation":[{"name":"Department of Cardiology Siyami Ersek Thoracic and Cardiovascular Surgery Center Training and Research Hospital Istanbul 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