{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:21:27Z","timestamp":1774448487299,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is unclear whether asymmetry itself plays a role in developing eccentric aortic regurgitation (<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>) in patients with tricuspid aortic valve (<jats:styled-content style=\"fixed-case\">TAV<\/jats:styled-content>). The aim of this study was to determine whether an asymmetric aortic valve structure may have association with the development of eccentric <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">TAV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of the 164 410 patients who underwent echocardiography between January 2006 and January 2018 at Dong\u2010A University Hospital, 306 (mean age 69.9\u00a0\u00b1\u00a012.6\u00a0years; 62% men) eccentric <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> were identified. After excluding patients with bicuspid and prolapsed <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content>, 104 patients who had eccentric <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">TAV<\/jats:styled-content> were enrolled for the study. Comprehensive echocardiographic <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content> cusp measurements were compared to those of 104 age\u2010 and gender\u2010matched control patients with central <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the eccentric and central <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> groups, 66 (63.5%) and 48 patients (46.2%) had asymmetric <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content>, respectively. Mean cusp height was significantly larger in the eccentric <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> group than in the central <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> group (1.8\u00a0\u00b1\u00a00.3\u00a0cm vs 1.7\u00a0\u00b1\u00a00.2\u00a0cm, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0002). Furthermore, the mean cusp area and average asymmetry index of the cusp area were also significantly larger in the eccentric <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> group than in the central <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> group (2.6\u00a0\u00b1\u00a00.8\u00a0cm<jats:sup>2<\/jats:sup> vs 2.3\u00a0\u00b1\u00a00.6\u00a0cm<jats:sup>2<\/jats:sup>, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001, and 7.1\u00a0\u00b1\u00a04.5% vs 4.9\u00a0\u00b1\u00a02.5%, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content> asymmetry indices of eccentric <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> were significantly larger than those of patients with central <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content>. These data suggest that the presence of asymmetric <jats:styled-content style=\"fixed-case\">AV<\/jats:styled-content> might have association with the development of eccentric <jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">TAV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14374","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T08:55:40Z","timestamp":1559292940000},"page":"1035-1040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Asymmetric aortic valve is related to development of eccentric aortic regurgitation in patients with tricuspid aortic valve"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9968-8276","authenticated-orcid":false,"given":"Tae\u2010Ho","family":"Park","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Dong\u2010A University College of Medicine Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo\u2010Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Dong\u2010A University College of Medicine Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Rak","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Dong\u2010A University College of Medicine Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungil","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Dong\u2010A University College of Medicine Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Sung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Dong\u2010A University College of Medicine Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moo\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Dong\u2010A University College of Medicine Busan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Dae","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Dong\u2010A University College of Medicine Busan South 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