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Severe SEC is often called \u201csludge,\u201d and its prognosis and treatment are still controversial. Current guidelines suggest the use of ultrasound enhancing agents (UEAs) when significant SEC is present. However, little is known about the utility of the UEAs in the differentiation between sludge and less severe SEC.<\/jats:p>","DOI":"10.1111\/echo.14405","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T13:35:41Z","timestamp":1561988141000},"page":"1413-1417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Differentiating spontaneous echo contrast, sludge, and thrombus in the left atrial appendage: Can ultrasound enhancing agents help?"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-4281","authenticated-orcid":false,"given":"Edith Liliana","family":"Posada\u2010Martinez","sequence":"first","affiliation":[{"name":"Cardiovascular Division Yale University New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Trejo\u2010Paredes","sequence":"additional","affiliation":[{"name":"Cardiovascular 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