{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:55:24Z","timestamp":1761562524951,"version":"3.40.5"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heart failure (<jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>) represents a deadly epidemic that nowadays affects more than 2% of the general population, representing a major public health concern that implies a high economic burden for the health system. Levosimendan in <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content> patients is usually used for its inotropic and vasodilator effects that act without myocardial oxygen consumption, differently from other inotropic drugs. The symptoms and hemodynamic profile improve together with the myocardial function, and this can be demonstrated by an echocardiographic examination. Currently, the available data about the effects of levosimendan assessed by echocardiography are still lacking. This review discusses the role of echocardiography in the evaluation of therapeutic effects of levosimendan in <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/echo.14419","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T15:05:45Z","timestamp":1562684745000},"page":"1566-1572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of levosimendan in heart failure: The role of echocardiography"],"prefix":"10.1111","volume":"36","author":[{"given":"Matteo","family":"Cameli","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eufemia","family":"Incampo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Navarri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3184-3006","authenticated-orcid":false,"given":"Giulia Elena","family":"Mandoli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1965-1773","authenticated-orcid":false,"given":"Carlotta","family":"Sciaccaluga","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca Maria","family":"Righini","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Palmerini","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00f2","family":"Sisti","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Mondillo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Lunghetti","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,9]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_12_2_1","DOI":"10.1136\/heart.83.5.596"},{"doi-asserted-by":"publisher","key":"e_1_2_12_3_1","DOI":"10.1136\/hrt.2003.025270"},{"doi-asserted-by":"publisher","key":"e_1_2_12_4_1","DOI":"10.1093\/eurheartj\/ehi044"},{"doi-asserted-by":"publisher","key":"e_1_2_12_5_1","DOI":"10.1161\/CIRCULATIONAHA.105.590091"},{"issue":"4","key":"e_1_2_12_6_1","first-page":"S18","article-title":"Pharmacologic therapies for acutely decompensated heart failure","volume":"3","author":"Fonarow GC","year":"2002","journal-title":"Rev Cardiovasc Med"},{"doi-asserted-by":"publisher","key":"e_1_2_12_7_1","DOI":"10.1002\/ejhf.592"},{"doi-asserted-by":"publisher","key":"e_1_2_12_8_1","DOI":"10.1007\/s00134-010-2073-4"},{"doi-asserted-by":"publisher","key":"e_1_2_12_9_1","DOI":"10.1016\/S0002-8703(99)70250-4"},{"doi-asserted-by":"publisher","key":"e_1_2_12_10_1","DOI":"10.1056\/NEJM199111213252103"},{"doi-asserted-by":"publisher","key":"e_1_2_12_11_1","DOI":"10.1016\/j.bbrc.2004.08.034"},{"doi-asserted-by":"publisher","key":"e_1_2_12_12_1","DOI":"10.1111\/jcpt.12067"},{"doi-asserted-by":"publisher","key":"e_1_2_12_13_1","DOI":"10.1016\/j.pharmthera.2007.01.008"},{"doi-asserted-by":"publisher","key":"e_1_2_12_14_1","DOI":"10.1161\/01.CIR.98.20.2141"},{"doi-asserted-by":"publisher","key":"e_1_2_12_15_1","DOI":"10.1067\/mcp.2000.110972"},{"doi-asserted-by":"publisher","key":"e_1_2_12_16_1","DOI":"10.1016\/S0014-2999(97)01108-4"},{"doi-asserted-by":"publisher","key":"e_1_2_12_17_1","DOI":"10.1097\/00005344-200104000-00003"},{"doi-asserted-by":"publisher","key":"e_1_2_12_18_1","DOI":"10.1097\/01.CCM.0000230244.17174.4F"},{"doi-asserted-by":"publisher","key":"e_1_2_12_19_1","DOI":"10.1097\/01.CCM.0000242157.19347.50"},{"doi-asserted-by":"publisher","key":"e_1_2_12_20_1","DOI":"10.1016\/S0140-6736(02)09455-2"},{"doi-asserted-by":"publisher","key":"e_1_2_12_21_1","DOI":"10.1016\/S0735-1097(00)00961-X"},{"doi-asserted-by":"publisher","key":"e_1_2_12_22_1","DOI":"10.1161\/01.CIR.102.18.2222"},{"doi-asserted-by":"publisher","key":"e_1_2_12_23_1","DOI":"10.1097\/FJC.0b013e31826b86aa"},{"doi-asserted-by":"publisher","key":"e_1_2_12_24_1","DOI":"10.1097\/01.fjc.0000189076.71730.f1"},{"doi-asserted-by":"publisher","key":"e_1_2_12_25_1","DOI":"10.1016\/j.echo.2008.07.016"},{"key":"e_1_2_12_26_1","first-page":"153","article-title":"Neurohumoral improvement and torsional dynamics in patients with heart failure after treatment with levosimendan","volume":"7","author":"Navarri R","year":"2014","journal-title":"Int J Cardiol Heart Vasc"},{"doi-asserted-by":"publisher","key":"e_1_2_12_27_1","DOI":"10.5603\/CJ.2011.0009"},{"key":"e_1_2_12_28_1","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1242\/jeb.205.19.2957","article-title":"Adaptive mechanisms of intracellular calcium homeostasis in mammalian hibernators","volume":"205","author":"Wang SQ","year":"2002","journal-title":"J Exp Biol"},{"doi-asserted-by":"publisher","key":"e_1_2_12_29_1","DOI":"10.1177\/147323000503300405"},{"doi-asserted-by":"publisher","key":"e_1_2_12_30_1","DOI":"10.1093\/eurheartj\/11.suppl_C.2"},{"doi-asserted-by":"publisher","key":"e_1_2_12_31_1","DOI":"10.1161\/CIRCULATIONAHA.107.722868"},{"doi-asserted-by":"publisher","key":"e_1_2_12_32_1","DOI":"10.1378\/chest.128.4.2633"},{"doi-asserted-by":"publisher","key":"e_1_2_12_33_1","DOI":"10.1136\/heart.89.11.1308"},{"doi-asserted-by":"publisher","key":"e_1_2_12_34_1","DOI":"10.1016\/j.echo.2005.08.016"},{"doi-asserted-by":"publisher","key":"e_1_2_12_35_1","DOI":"10.1016\/j.amjcard.2005.03.092"},{"doi-asserted-by":"publisher","key":"e_1_2_12_36_1","DOI":"10.1097\/01.CCM.0000257326.96342.57"},{"doi-asserted-by":"publisher","key":"e_1_2_12_37_1","DOI":"10.1016\/j.amjcard.2006.06.052"},{"doi-asserted-by":"publisher","key":"e_1_2_12_38_1","DOI":"10.5603\/KP.2013.0258"},{"doi-asserted-by":"publisher","key":"e_1_2_12_39_1","DOI":"10.1053\/euhj.1999.2581"},{"doi-asserted-by":"publisher","key":"e_1_2_12_40_1","DOI":"10.1161\/01.CIR.86.4.1317"},{"doi-asserted-by":"publisher","key":"e_1_2_12_41_1","DOI":"10.1016\/0735-1097(88)90416-0"},{"doi-asserted-by":"publisher","key":"e_1_2_12_42_1","DOI":"10.1023\/A:1005810212706"},{"doi-asserted-by":"publisher","key":"e_1_2_12_43_1","DOI":"10.1002\/clc.20332"},{"doi-asserted-by":"publisher","key":"e_1_2_12_44_1","DOI":"10.1016\/S0828-282X(09)70721-4"},{"doi-asserted-by":"publisher","key":"e_1_2_12_45_1","DOI":"10.7863\/jum.2011.30.1.71"},{"doi-asserted-by":"publisher","key":"e_1_2_12_46_1","DOI":"10.1136\/heartjnl-2014-305538"},{"doi-asserted-by":"publisher","key":"e_1_2_12_47_1","DOI":"10.1093\/eurheartj\/ehv529"},{"doi-asserted-by":"publisher","key":"e_1_2_12_48_1","DOI":"10.1016\/j.jcmg.2015.07.004"},{"doi-asserted-by":"publisher","key":"e_1_2_12_49_1","DOI":"10.1186\/1476-7120-8-14"},{"key":"e_1_2_12_50_1","first-page":"e1372","article-title":"Role of speckle tracking echocardiography in dilated cardiomyopathy: a review","volume":"9","author":"Murtaza G","year":"2017","journal-title":"Cureus"},{"doi-asserted-by":"publisher","key":"e_1_2_12_51_1","DOI":"10.1016\/j.amjcard.2008.06.060"},{"doi-asserted-by":"publisher","key":"e_1_2_12_52_1","DOI":"10.1016\/j.echo.2008.03.002"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.14419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.14419","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T11:35:44Z","timestamp":1694259344000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.14419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,9]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/echo.14419"],"URL":"https:\/\/doi.org\/10.1111\/echo.14419","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"type":"print","value":"0742-2822"},{"type":"electronic","value":"1540-8175"}],"subject":[],"published":{"date-parts":[[2019,7,9]]},"assertion":[{"value":"2019-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}