{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:28:05Z","timestamp":1768012085718,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe clinical and echocardiographic characteristics associated with reverse left ventricular (LV) remodeling after 6\u00a0months of cardiac resynchronization therapy (CRT) in patients with nonischemic dilated cardiomyopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four consecutive patients underwent 2D and 3D echocardiography before and after 6\u00a0months of CRT implant. Several echocardiographic parameters including global longitudinal strain (GLS) and 3D mechanical dyssynchrony (MD) index were calculated. CRT response was defined as a decrease in LV end\u2010systolic volume (LVESV) of at least 10% at follow\u2010up. Patients were divided in two groups according to CRT response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cardiac resynchronization therapy responder (CRTR+) rate was 50%. Nonresponder (CRTR\u2212) patients showed a less significant improvement in NYHA class at follow\u2010up. At baseline, CRTR\u2212 presented with higher LV end\u2010diastolic volume (LVEDV) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.031), LVESV (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.024), lower left ventricular ejection fraction (LVEF) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) and less negative GLS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), and with higher diastolic dysfunction, more impaired right ventricle (RV), and higher pulmonary artery systolic pressure (PASP) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). No significant differences in echocardiographic parameters of MD were found. Univariate determinants of CRTR+ were LVEF (OR\u00a0=\u00a01.59, CI 95%\u00a0=\u00a01.13\u20132.22, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) and TAPSE (OR 1.21, CI 95%\u00a0=\u00a01.024\u20131.429, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025). A ROC curve analysis showed a cutoff value of LVEF of 22.15% significantly related to CRTR+ (SE 80%, SP 50%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that end\u2010stage HF patients, presenting before CRT with LVEF &lt;22.15%, may not benefit from the procedure after 6\u00a0months. Mechanical dyssyncronicity did not provide additional information to improve candidate selection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14425","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T13:36:51Z","timestamp":1561988211000},"page":"1475-1481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["2D\/3D Echocardiographic features of patients with reverse remodeling after cardiac resynchronization therapy"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8948-4122","authenticated-orcid":false,"given":"Sara","family":"Cimino","sequence":"first","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences, \u201cSapienza\u201d University of Rome Policlinico Umberto I Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3225-8378","authenticated-orcid":false,"given":"Viviana","family":"Maestrini","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences, \u201cSapienza\u201d University of Rome Policlinico Umberto I Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Cantisani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences, \u201cSapienza\u201d University of Rome Policlinico Umberto I Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Petronilli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences, \u201cSapienza\u201d University of Rome Policlinico Umberto I Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Filomena","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences, \u201cSapienza\u201d University of Rome Policlinico Umberto I Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Gatto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences, \u201cSapienza\u201d University of Rome Policlinico Umberto I Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia I.","family":"Birtolo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences, \u201cSapienza\u201d University of Rome Policlinico Umberto I Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agostino","family":"Piro","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences, \u201cSapienza\u201d University of Rome Policlinico Umberto I Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Lavalle","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences, \u201cSapienza\u201d University of Rome Policlinico Umberto I Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3186-1797","authenticated-orcid":false,"given":"Luciano","family":"Agati","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences, \u201cSapienza\u201d University of Rome Policlinico Umberto I Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.053"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039105.49749.6F"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.634444"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.01056.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.07.025"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.11.024"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.02.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp034"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.00011.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02240-8"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.03.032"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.08.082"},{"key":"e_1_2_7_15_1","first-page":"1","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang RM","year":"2015","journal-title":"Eur Heart J Cardiovasc Imag"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2010.09.021"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes295"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jex067"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000116765.43251.D7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(07)70760-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey029"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.051"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.11.020"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009540"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq009"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.000326"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.11.061"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00877-2"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2009.02436.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.126193"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.14425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.14425","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T11:34:34Z","timestamp":1694259274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.14425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/echo.14425"],"URL":"https:\/\/doi.org\/10.1111\/echo.14425","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"2019-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}