{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:32:58Z","timestamp":1787682778963,"version":"build-2784847793"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cogan's syndrome is a rare disorder characterized by the coexistence of ocular and audio\u2010vestibular manifestations. Systemic manifestations are quite unusual with pan\u2010vasculitis and cardiac involvement reported in the form of aortitis with aortic aneurysm, dissection, or extremely rare aortic valve perforation. Hereby, we report a case of a 56\u2010year\u2010old woman presented with ocular, audio\u2010vestibular, and systemic manifestations with medium\u2010sized vasculitis in the form of multiple splenic artery aneurysms, superior mesenteric artery thrombosis, and cardiovascular involvement in the form of aortic regurgitation due to noncoronary cusp perforation. To the best of our knowledge, this is the second case to report aortic perforation in the setting of Cogan's syndrome.<\/jats:p>","DOI":"10.1111\/echo.14428","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T14:13:43Z","timestamp":1561644823000},"page":"1590-1593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Aortic valve perforation in the setting of Cogan's syndrome"],"prefix":"10.1111","volume":"36","author":[{"given":"Asmaa","family":"Beltagy","sequence":"first","affiliation":[{"name":"Rheumatology Unit Department of Internal Medicine Faculty of Medicine University of Alexandria Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouran","family":"Eshak","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Department of Internal Medicine Faculty of Medicine University of Alexandria Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-9049","authenticated-orcid":false,"given":"Mahmoud Hassan","family":"Abdelnabi","sequence":"additional","affiliation":[{"name":"Cardiology and Angiology Unit Department of Clinical and Experimental Internal Medicine Medical Research Institute University of Alexandria Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Almaghraby","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine University of Alexandria Alexandria Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Magdy","sequence":"additional","affiliation":[{"name":"Hepatology Unit Department of Internal Medicine Faculty of Medicine University of Alexandria Alexandria 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