{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:25:08Z","timestamp":1790735108973,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Lipedema is a barely recognized and poorly diagnosed, but common disease affecting almost exclusively female patients. The pathomechanism of lipedema is not known, and clinically, it is a bilateral, symmetrical, disproportional fatty enlargement of the lower half of the body, the disease does not affect the feet, and the upper extremities are often involved. Since lipedema is associated with increased aortic stiffness and altered left ventricular\u00a0(LV) rotational mechanics, the present study was designed to compare the size and function of the mitral annulus (MA) between lipedema patients and controls by three\u2010dimensional speckle\u2010tracking echocardiography (3DSTE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four patients with stage 2 lipedema and 48 age\u2010, gender\u2010, and body mass index\u2010matched healthy control patients were included in the study. Each person from the lipedema and the control groups underwent two\u2010dimensional Doppler echocardiography and 3DSTE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly enlarged left atrial diameter, LV\u00a0end\u2010diastolic diameter and volume, and LV\u00a0end\u2010systolic volume could be detected in lipedema patients as compared to controls. None of the lipedema patients and controls showed \u2265grade 1 mitral or tricuspid regurgitation. Dilated end\u2010systolic and end\u2010diastolic MA diameter, area, and perimeter could be demonstrated in lipedema patients as compared to controls, and these changes were accompanied by impaired MA\u00a0fractional area change at rest. Following 1\u2010hour use of compression stockings, no significant improvement was seen in these parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lipedema is associated with MA enlargement and functional impairment. The use of compression stockings does not improve these alterations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14429","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T10:09:43Z","timestamp":1563444583000},"page":"1482-1491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The mitral annulus in lipedema: Insights from the three\u2010dimensional speckle\u2010tracking echocardiographic MAGYAR\u2010Path Study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7570-6214","authenticated-orcid":false,"given":"Attila","family":"Nemes","sequence":"first","affiliation":[{"name":"2nd Department of Medicine and Cardiology Centre Albert Szent\u2010Gy\u00f6rgyi Clinical Center, University of Szeged Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Cardiology Szent R\u00f3kus Hospital Baja Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1rp\u00e1d","family":"Korm\u00e1nyos","sequence":"additional","affiliation":[{"name":"2nd Department of Medicine and Cardiology Centre Albert Szent\u2010Gy\u00f6rgyi Clinical Center, University of Szeged Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Domsik","sequence":"additional","affiliation":[{"name":"2nd Department of Medicine and Cardiology Centre Albert Szent\u2010Gy\u00f6rgyi Clinical Center, University of Szeged Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Kalapos","sequence":"additional","affiliation":[{"name":"2nd Department of Medicine and Cardiology Centre Albert Szent\u2010Gy\u00f6rgyi Clinical Center, University of Szeged Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgyike \u00c1.","family":"Piros","sequence":"additional","affiliation":[{"name":"2nd Department of Medicine and Cardiology Centre Albert Szent\u2010Gy\u00f6rgyi Clinical Center, University of Szeged Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lajos","family":"Kem\u00e9ny","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Albert Szent\u2010Gy\u00f6rgyi Clinical Center, University of Szeged Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Forster","sequence":"additional","affiliation":[{"name":"2nd Department of Medicine and Cardiology Centre Albert Szent\u2010Gy\u00f6rgyi Clinical Center, University of Szeged Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u0151z\u0151","family":"Szolnoky","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Albert Szent\u2010Gy\u00f6rgyi Clinical Center, University of Szeged Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"541","article-title":"Diagnosis and treatment of primary lymphedema. Consensus document of the International Union of Phlebology (IUP)\u20102013.","volume":"32","author":"Lee BB","year":"2013","journal-title":"Int Angiol"},{"key":"e_1_2_7_3_1","first-page":"71","article-title":"Lipedema is associated with increased aortic stiffness","volume":"45","author":"Szolnoky G","year":"2012","journal-title":"Lymphology"},{"key":"e_1_2_7_4_1","first-page":"102","article-title":"Left ventricular rotational mechanics differ between lipedema and lymphedema: Insights from the three\u2010dimensional speckle\u2010tracking echocardiographic MAGYAR\u2010Path Study","volume":"51","author":"Nemes A","year":"2018","journal-title":"Lymphology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1556\/OH.2012.29466"},{"key":"e_1_2_7_7_1","first-page":"304","article-title":"Cardiac amyloidosis associated with enlargement and functional impairment of the mitral annulus: Insights from the three\u2010dimensional speckle\u2010tracking echocardiographic MAGYAR\u2010Path Study","volume":"26","author":"Nemes A","year":"2017","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.01.026"},{"key":"e_1_2_7_9_1","first-page":"31","article-title":"Non\u2010compaction cardiomyopathy is associated with mitral annulus enlargement and functional impairment: a real\u2010time three\u2010dimensional echocardiographic study","volume":"17","author":"Nemes A","year":"2008","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_7_10_1","first-page":"426","article-title":"Comparison of three portable instruments to measure compression pressure","volume":"29","author":"Partsch H","year":"2010","journal-title":"Int Angiol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2017.07.006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.05.014"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1758-8111.2012.00045.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-4307-9_8"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.14429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.14429","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T11:34:42Z","timestamp":1694259282000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.14429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,18]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/echo.14429"],"URL":"https:\/\/doi.org\/10.1111\/echo.14429","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,18]]},"assertion":[{"value":"2018-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}