{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T01:26:31Z","timestamp":1786238791152,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Division of Neonatology at the Children's Hospital of Philadelphia"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary artery acceleration time measured by echocardiography inversely correlates with pulmonary artery pressures in adults and children older than 1\u00a0year of age. There is a paucity of data investigating this relationship in young children, particularly among preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize the relationship between pulmonary artery acceleration time (<jats:styled-content style=\"fixed-case\">PAAT<\/jats:styled-content>) and pulmonary artery pressures in infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/Methods<\/jats:title><jats:p>Patients \u2264\u00a01\u00a0year of age at Children's Hospital of Philadelphia between 2011 and 2017 were reviewed. Infants with congenital heart disease were excluded, except those with a patent ductus arteriosus\u00a0(PDA), atrial septal defect\u00a0(ASD), or ventricular septal defect\u00a0(VSD). Linear regression analysis was used to assess the correlation between <jats:styled-content style=\"fixed-case\">PAAT<\/jats:styled-content> measured by echocardiography and systolic pulmonary artery pressure, mean pulmonary artery pressure, and indexed pulmonary vascular resistance from cardiac catheterization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010seven infants were included, of which 61% were preterm and 49% had a diagnosis of bronchopulmonary dysplasia. The median postmenstrual age and weight at catheterization were 51.1\u00a0weeks (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 35.8\u201367.9\u00a0weeks) and 4400\u00a0g (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 3100\u20136500\u00a0g), respectively. Forty\u2010four infants (77%) had a patent ductus arteriosus (<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>). There was a weak inverse correlation between <jats:styled-content style=\"fixed-case\">PAAT<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">mPAP<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.35, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01), <jats:styled-content style=\"fixed-case\">sPAP<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.29, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), and <jats:styled-content style=\"fixed-case\">PVR<\/jats:styled-content>i (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.29, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a weak inverse relationship between <jats:styled-content style=\"fixed-case\">PAAT<\/jats:styled-content> and pulmonary artery pressures. This relationship is less robust in our population of infants with a high incidence of <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>s compared to previous studies in older children. Thus, <jats:styled-content style=\"fixed-case\">PAAT<\/jats:styled-content> may be less clinically meaningful for diagnosing pulmonary arterial hypertension in infants, particularly those with <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14430","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T13:35:05Z","timestamp":1561988105000},"page":"1524-1531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Relationship between pulmonary artery acceleration time and pulmonary artery pressures in infants"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1638-1739","authenticated-orcid":false,"given":"Jessica S.","family":"Gaulton","sequence":"first","affiliation":[{"name":"Neonatology Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Mercer\u2010Rosa","sequence":"additional","affiliation":[{"name":"Cardiology Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Glatz","sequence":"additional","affiliation":[{"name":"Cardiology Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik A.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Neonatology Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Capone","sequence":"additional","affiliation":[{"name":"Cardiology Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Scott","sequence":"additional","affiliation":[{"name":"Cardiology Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Appel","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason Z.","family":"Stoller","sequence":"additional","affiliation":[{"name":"Neonatology Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda V.","family":"Fraga","sequence":"additional","affiliation":[{"name":"Neonatology Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.029"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0971"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-307200"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008142"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.07.032"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000329"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.70.4.657"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.82.3.F243"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201409-1594OC"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.72.1.F14"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)91189-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.2.302"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80047-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.56.2.158"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.10.016"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90646-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.08.013"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0520-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.005336"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.07.054"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.02.006"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-1528"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-3506"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.01.015"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.03.012"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-019-01540-w"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.03.008"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes309"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.06.022"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2014.10.011"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.006894"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.14430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.14430","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T11:35:16Z","timestamp":1694259316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.14430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/echo.14430"],"URL":"https:\/\/doi.org\/10.1111\/echo.14430","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"2018-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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