{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:00:32Z","timestamp":1747184432983,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671762","81630048"],"award-info":[{"award-number":["81671762","81630048"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The primary aim of this study was to evaluate early changes in cardiac function after anthracycline therapy with layer\u2010specific speckle\u2010tracking echocardiography (<jats:styled-content style=\"fixed-case\">STE<\/jats:styled-content>) and mechanical dys\u2010synchrony.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 78 breast cancer patients (ranging 31~72\u00a0years) exposed to anthracycline treatment were recruited in this study. All patients received both conventional two\u2010dimensional speckle\u2010tracking echocardiographs at baseline, as well as after the completion of 2 and 4 cycles of the regimen. Layer\u2010specific longitudinal strain (<jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>) and circumferential strain (<jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content>) of the 3 myocardial layers (endocardium, mid\u2010myocardium, and epicardium) were automatically measured. Peak systolic dispersion (<jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content>) was defined as the standard deviation of the time to peak strain of the 18 segments, divided by the <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content> interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in conventional echocardiographic parameters during treatment (all <jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>.05). Peak endocardium <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> at basal level decreased significantly after 2 and 4 cycles compared with baseline (both <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.001), while <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content> significantly increased in that same period versus baseline (both <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.000). Endocardium and mid\u2010myocardium <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>, peak mid\u2010myocardium and epicardium <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> at the basal level, peak <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> of all three layers at the papillary level, and peak endocardium and mid\u2010myocardium <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> at the apical level all significantly decreased after 4 cycles, compared with baseline and 2 cycles (all <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that myocardial deformation impairment occurred as early as 2 cycles after anthracycline chemotherapy. Endocardium <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> at the basal level and left ventricular dys\u2010synchrony index <jats:styled-content style=\"fixed-case\">PSD<\/jats:styled-content> were the initial cardiac abnormalities in anthracycline\u2010treated breast cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14460","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T15:16:42Z","timestamp":1566919002000},"page":"1675-1681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The early alteration of left ventricular strain and dys\u2010synchrony index in breast cancer patients undergoing anthracycline therapy using layer\u2010specific strain analysis"],"prefix":"10.1111","volume":"36","author":[{"given":"Hairu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ultrasound The Second Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"Key Laboratories of Myocardial Ischemia Mechanism and Treatment Ministry of Education Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"Key Laboratories of Myocardial Ischemia Mechanism and Treatment Ministry of Education Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"Key Laboratories of Myocardial Ischemia Mechanism and Treatment Ministry of Education Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"Key Laboratories of Myocardial Ischemia Mechanism and Treatment Ministry of Education Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6674-8714","authenticated-orcid":false,"given":"Jiawei","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Affiliated Hospital of Harbin Medical University Harbin China"},{"name":"Key Laboratories of Myocardial Ischemia Mechanism and Treatment Ministry of Education Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013777"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.068"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-5-710"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jer187"},{"issue":"5","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/HCO.0000000000000541","article-title":"Applications of left ventricular strain measurements to patients undergoing chemotherapy","volume":"33","author":"Clasen SC","year":"2018","journal-title":"Curr Opin Cardiol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.07.017"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv529"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2011.30.1.71"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.10.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.11.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.03.015"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(95)02502-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.789"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.12.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr391"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.07.012"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpy175"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-014-0214-8"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.03.025"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.03.010"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018181253"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-018-0980-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.194118"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-17-0874"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(86)90559-4"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(90)90071-P"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/10976640600737664"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jes143"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.03.019"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2016.12.015"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.09.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.11.194"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.14460","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:29:01Z","timestamp":1694212141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.14460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,27]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/echo.14460"],"URL":"https:\/\/doi.org\/10.1111\/echo.14460","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"type":"print","value":"0742-2822"},{"type":"electronic","value":"1540-8175"}],"subject":[],"published":{"date-parts":[[2019,8,27]]},"assertion":[{"value":"2019-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}