{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:13:36Z","timestamp":1782782016880,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The concept of \u201cred flags\u201d has been particularly useful in the etiologic diagnosis of cardiomyopathies such as Fabry disease, as early detection is often essential for treatment response and outcomes. The present study sought to describe the echocardiographic features that may differentiate Fabry cardiomyopathy from sarcomeric hypertrophic cardiomyopathy (HCM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty patients with left ventricular (LV) hypertrophy were prospectively included and divided into two groups: the Fabry group (20) and the sarcomeric HCM group (20). The two groups were matched for LV hypertrophy (similar maximum wall thickness and indexed LV mass) and age. All patients underwent full echocardiographic evaluation including ventricular strain analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Fabry group had significantly lower LV ejection fraction (63\u00a0\u00b1\u00a07 vs 72\u00a0\u00b1\u00a07%, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.001) and higher LV end\u2010systolic diameter (28\u00a0\u00b1\u00a07 vs 22\u00a0\u00b1\u00a05\u00a0mm, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.004). LV hypertrophy in Fabry patients was more often concentric, with a significantly lower interventricular septum\/posterior wall ratio (1.22\u00a0\u00b1\u00a00.63 vs 1.55\u00a0\u00b1\u00a00.66, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.001). Fabry patients had more reduced regional longitudinal strain in the inferolateral part of the LV (\u22129\u00a0\u00b1\u00a05 vs \u201316\u00a0\u00b1\u00a07%), and RV free wall longitudinal strain was also worse in Fabry patients (\u221223\u00a0\u00b1\u00a06 vs \u201328\u00a0\u00b1\u00a05%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.027).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These parameters are promising echocardiographic features to identify patients with Fabry cardiomyopathy and may help for the detection and subsequent management of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14508","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T16:26:06Z","timestamp":1572366366000},"page":"2041-2049","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Echocardiographic features of Fabry cardiomyopathy\u2014Comparison with hypertrophy\u2010matched sarcomeric hypertrophic cardiomyopathy"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2578-6356","authenticated-orcid":false,"given":"Sebastian","family":"Militaru","sequence":"first","affiliation":[{"name":"Department of Cardiology Expert Center for Rare Genetic Cardiovascular Diseases Emergency Institute of Cardiovascular Diseases \u201cProf. Dr. C. C. Iliescu\u201d Bucharest Romania"},{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d \u2013 Euroecolab Bucharest Romania"},{"name":"University of Medicine and Pharmacy Craiova Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxandra","family":"Jurcu\u021b","sequence":"additional","affiliation":[{"name":"Department of Cardiology Expert Center for Rare Genetic Cardiovascular Diseases Emergency Institute of Cardiovascular Diseases \u201cProf. Dr. C. C. Iliescu\u201d Bucharest Romania"},{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d \u2013 Euroecolab Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Cardiology Expert Center for Rare Genetic Cardiovascular Diseases Emergency Institute of Cardiovascular Diseases \u201cProf. Dr. C. C. Iliescu\u201d Bucharest Romania"},{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d \u2013 Euroecolab Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Ro\u015fca","sequence":"additional","affiliation":[{"name":"Department of Cardiology Expert Center for Rare Genetic Cardiovascular Diseases Emergency Institute of Cardiovascular Diseases \u201cProf. Dr. C. C. Iliescu\u201d Bucharest Romania"},{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d \u2013 Euroecolab Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Ginghina","sequence":"additional","affiliation":[{"name":"Department of Cardiology Expert Center for Rare Genetic Cardiovascular Diseases Emergency Institute of Cardiovascular Diseases \u201cProf. Dr. C. C. Iliescu\u201d Bucharest Romania"},{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d \u2013 Euroecolab Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan A.","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Expert Center for Rare Genetic Cardiovascular Diseases Emergency Institute of Cardiovascular Diseases \u201cProf. Dr. C. C. Iliescu\u201d Bucharest Romania"},{"name":"University of Medicine and Pharmacy \u201cCarol Davila\u201d \u2013 Euroecolab Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu284"},{"key":"e_1_2_7_3_1","volume-title":"Natural History of Fabry Disease","author":"Mehta A","year":"2006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.204586"},{"issue":"12","key":"e_1_2_7_5_1","first-page":"1313","article-title":"Multimodality imaging in Fabry cardiomyopathy: from early diagnosis to therapeutic targets","volume":"19","author":"Militaru S","year":"2018","journal-title":"Eur Hear J Cardiovasc Imaging"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-016-0233-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi258"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2014-102797"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2010.10.017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht098"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.2.548"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.174287"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2004.01835.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx391"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.07.015"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs397"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.063818"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-17"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.05.006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.071"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000538"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.06.046"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.06.019"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.794529"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2012.01704.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.11.014"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.14508","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T06:07:50Z","timestamp":1694239670000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.14508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/echo.14508"],"URL":"https:\/\/doi.org\/10.1111\/echo.14508","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,29]]},"assertion":[{"value":"2019-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}