{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T19:00:37Z","timestamp":1763578837415,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hypereosinophilic syndrome (HES) is a very heterogeneous group of disorders with varied etiologies characterized by peripheral eosinophilia and eosinophilic tissue\/end\u2010organ damage. Three\u2010dimensional speckle\u2010tracking echocardiography (3DSTE) was used for assessment of left ventricular (LV) rotational mechanics in HES patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study comprised 13 HES patients, from which one patient was excluded due to insufficient image quality. The remaining patient population consisted of 12 HES cases (mean age: 59.7\u00a0\u00b1\u00a013.7\u00a0years, eight males). The control group consisted of 36 healthy volunteers (mean age: 52.9\u00a0\u00b1\u00a08.3\u00a0years, 23 males). 3DSTE was used for the evaluation of LV rotational abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both LV apical rotation (4.86\u00a0\u00b1\u00a01.92 degree vs 10.07\u00a0\u00b1\u00a03.92 degree, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) and LV twist (8.52\u00a0\u00b1\u00a02.79 degree vs 14.41\u00a0\u00b1\u00a04.26 degree, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) showed significant deteriorations in most of HES patients. Time\u2010to\u2010peak LV apical rotation (380\u00a0\u00b1\u00a0115\u00a0ms vs 344\u00a0\u00b1\u00a069\u00a0ms, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.56), LV basal rotation (335\u00a0\u00b1\u00a0148\u00a0ms vs 337\u00a0\u00b1\u00a0111\u00a0ms, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.89), and LV twist (348\u00a0\u00b1\u00a091\u00a0ms vs 320\u00a0\u00b1\u00a060\u00a0ms, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.64) were not significantly different between HES patients and controls. No correlations could be detected between absolute eosinophil count and eosinophil ratio and apical LV rotation (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.12, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.51 and <jats:italic>r<\/jats:italic>\u00a0=\u00a00.23, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.45, respectively) and LV twist (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.24, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.39 and <jats:italic>r<\/jats:italic>\u00a0=\u00a00.31, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.34, respectively). In two subjects, the absence of LV twist called LV \u201crigid body rotation\u201d (RBR) was detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Reduced LV apical rotation and twist could be demonstrated in HES. LV\u2010RBR could be detected in some HES patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14517","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T15:37:19Z","timestamp":1573054639000},"page":"2064-2069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Left ventricular rotational mechanics in hypereosinophilic syndrome\u2014Analysis from the three\u2010dimensional speckle\u2010tracking echocardiographic MAGYAR\u2010Path Study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7570-6214","authenticated-orcid":false,"given":"Attila","family":"Nemes","sequence":"first","affiliation":[{"name":"2nd Department of Medicine and Cardiology Centre Medical Faculty Albert Szent\u2010Gy\u00f6rgyi Clinical Center University of Szeged Szeged 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