{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:25:27Z","timestamp":1790965527190,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T00:00:00Z","timestamp":1581724800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Pulmonary artery diastolic pressure (PADP) correlates closely with pulmonary wedge pressure (PAWP); therefore, we sought to evaluate whether an algorithm based on PADP assessment by the Doppler pulmonary regurgitation (PR) end\u2010diastolic gradient (PRG) may aid in estimating increased PAWP in cardiac patients with reduced or preserved left ventricular (LV) ejection fraction (EF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Right heart catheterization, with estimation of PAWP, right atrial pressure (RAP), PADP, and Doppler echocardiography, was carried out in 183 patients with coronary artery disease (n\u00a0=\u00a063), dilated cardiomyopathy (n\u00a0=\u00a052), or aortic stenosis (n\u00a0=\u00a068). One\u2010hundred and seventeen patients had LV EF &lt;50%. We measured the pressure gradients across the tricuspid and pulmonary valves from tricuspid regurgitation (TRV) and PR velocities. Doppler\u2010estimated PADP (e\u2010PADP) was obtained by adding the estimated RAP to PRG. An algorithm based on e\u2010PADP to predict PAWP, that included TRV, left atrial volume index, and mitral E\/A, was developed and validated in derivation (n\u00a0=\u00a090) and validation (n\u00a0=\u00a093) subgroups. Both invasive PADP (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.92, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and e\u2010PADP (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.72, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) correlated closely with PAWP, and e\u2010PADP predicted PAWP (AUC: 0.85, CI: 0.79\u20100.91) with a 94% positive predictive value (PPV) and a 55% negative predictive value (NPV), after exclusion of five patients with precapillary pulmonary hypertension. The e\u2010PADP\u2010based algorithm predicted PAWP with higher accuracy (PPV\u00a0=\u00a094%; NPV\u00a0=\u00a067%; accuracy\u00a0=\u00a085%; kappa: 0.65, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) than the ASE\u2010EACVI 2016 recommendations (PPV\u00a0=\u00a097%; NPV\u00a0=\u00a047%; accuracy\u00a0=\u00a068% undetermined\u00a0=\u00a018.9%; kappa: 0.15, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An algorithm based on noninvasively e\u2010PADP can accurately predict increased PAWP in patients with cardiac disease and reduced or preserved LV EF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14581","type":"journal-article","created":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T11:48:31Z","timestamp":1581767311000},"page":"215-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Estimation of increased pulmonary wedge pressure by an algorithm based on noninvasively measured pulmonary diastolic pressure in cardiac patients independent of left ventricular ejection fraction"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-5011","authenticated-orcid":false,"given":"Paolo","family":"Barbier","sequence":"first","affiliation":[{"name":"Imaging Department Jilin Heart Hospital Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuono","family":"Cucco","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Unit 1 Cardiovascular and Thoracic Department University of Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Guglielmo","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino IRCCS Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Simioniuc","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Unit 1 Cardiovascular and Thoracic Department University of Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Fabiani","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Unit 1 Cardiovascular and Thoracic Department University of Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Riccardo","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Unit 1 Cardiovascular and Thoracic Department University of Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Savioli","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Policlinico San Matteo Emergency Department University of Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank Lloyd","family":"Dini","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Unit 1 Cardiovascular and Thoracic Department University of Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.74.3.484"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.42.1.75"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew082"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jex067"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.01.058"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(14)80414-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mje.2003.8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.033"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(96)90475-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90583-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jeq047"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.04.055"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2011.07.004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002161"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002530"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.779223"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02864-3"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.01.051"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.14581","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:27:26Z","timestamp":1692847646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.14581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/echo.14581"],"URL":"https:\/\/doi.org\/10.1111\/echo.14581","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"2019-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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