{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:37:08Z","timestamp":1789425428224,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T00:00:00Z","timestamp":1580428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"crossref","award":["KJ2018A1003"],"award-info":[{"award-number":["KJ2018A1003"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Development Fund Project of the First Affiliated Hospital of Bengbu Medical College","award":["Byyfykj201712"],"award-info":[{"award-number":["Byyfykj201712"]}]},{"name":"Key Project of Natural Science Foundation of Bengbu Medical College","award":["BYKY1864ZD"],"award-info":[{"award-number":["BYKY1864ZD"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore endothelial function and plasma matrix metalloproteinase\u20102 levels and their association with the size and elastic properties of the ascending aorta in the first\u2010degree relatives (FDRs) with tricuspid aortic valve (TAV) of individuals with bicuspid aortic valve (BAV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six patients with BAV without significant valvular dysfunction, 35 FDRs with TAV, and 29 matched healthy controls were analyzed. Two\u2010dimensional echocardiography and high\u2010resolution ultrasound were applied to evaluate the size and elasticity of the ascending aorta and the flow\u2010mediated vasodilation (FMD) of the brachial artery in response to hyperemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The aortic diameter was larger in the BAV patients than in the FDRs and controls, and the aortic elastic properties showed larger decreases in the BAV patients. The FDRs had a larger aortic diameter and more impaired elastic properties than the controls. The BAV patients had a significantly lower FMD than the FDRs and controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), while the FMD was lower in the FDRs than in the controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The plasma MMP\u20102 levels were significantly higher in the BAV patients than in the FDRs (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) and controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Additionally, the FDRs had higher plasma MMP\u20102 levels than the controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Pearson correlation analysis revealed that the aortic diameter, distensibility, stiffness index, and strain were significantly associated with FMD and plasma MMP\u20102 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aortic enlargement and impaired elasticity in the FDRs with TAV were associated with impaired endothelial function and increased plasma MMP\u20102 concentrations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14594","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T09:34:07Z","timestamp":1580463247000},"page":"207-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endothelial function and plasma matrix metalloproteinase\u20102 levels and their association with the size and elastic properties of the ascending aorta in first\u2010degree relatives of bicuspid aortic valve patients"],"prefix":"10.1111","volume":"37","author":[{"given":"Yang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Bengbu Medical College Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5065-0058","authenticated-orcid":false,"given":"Yi\u2010Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory The First Affiliated Hospital of Bengbu Medical College Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Bengbu Medical College Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Bengbu Medical College Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Bengbu Medical College Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Bengbu Medical College Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9351-4147","authenticated-orcid":false,"given":"Yi\u2010Xue","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Bengbu Medical College Bengbu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.073"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-016-0876-2"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.08.080"},{"key":"e_1_2_5_5_1","first-page":"189","article-title":"Aortic elastic properties and left ventricular diastolic function in patients with isolated bicuspid aortic valve","volume":"21","author":"Bilen E","year":"2012","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.12.013"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007851"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000027905.26586.E8"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.6.H2319"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.65.5.1130"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2004.06.007"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-305509"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2018.01.012"},{"key":"e_1_2_5_14_1","first-page":"603","article-title":"Familial clustering of bicuspid aortic valve and its relationship with aortic dilation in first\u2010degree relatives","volume":"105","author":"Galian\u2010Gay L","year":"2019","journal-title":"Heart"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.12.046"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14167"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mje.2002.120202"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.01.046"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00335-3"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm528"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1207059"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev151"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31872"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.027"},{"key":"e_1_2_5_26_1","first-page":"150","article-title":"A pilot project of familial screening in patients with bicuspid aortic valve disease","volume":"22","author":"Panayotova R","year":"2013","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.66.908"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.6528"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)00435-X"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1207059"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.11.015"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.02.243"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/RTI.0000000000000197"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.14594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.14594","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T03:27:03Z","timestamp":1692847623000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.14594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,31]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/echo.14594"],"URL":"https:\/\/doi.org\/10.1111\/echo.14594","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,31]]},"assertion":[{"value":"2020-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}